1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
The Pathway to Prevention (P2P) for ME/CFS: A Dangerous Process
Gabby Klein gives an overview of the P2P process, shedding light on the pitfalls with advice as to what we can do in protest ...
Discuss the article on the Forums.

Article: State of the Knowledge Workshop at the NIH: Pathogens II - Epstein Barr virus and the Enter

Discussion in 'Phoenix Rising Articles' started by Phoenix Rising Team, Apr 17, 2011.

  1. Phoenix Rising Team

    Phoenix Rising Team

    Messages:
    650
    Likes:
    1,011
  2. currer

    currer Senior Member

    Messages:
    1,324
    Likes:
    774
    This is well written up Cort, thanks for the overview.
    What I womder is, whether any of this research can account for the parent - child transmission of CFS/ME which we see?
  3. Enid

    Enid Senior Member

    Messages:
    3,309
    Likes:
    840
    UK
    Many thanks again for this superb overview Cort - personally never doubted the viral(s) cause and maintenance of ME/CFS so this area of particular interest (sort of catch the blighters in the first place).
  4. Dorothy

    Dorothy

    Messages:
    49
    Likes:
    0
    Thanks Cort for this article!!! I'd like to add one more study to your list of Straus publications - namely the infamous 1989 study published in the Journal of Clinical Psychiatry (Kruesi M, Dale J, Straus SE, Psychiatric diagnoses in patients who have Chronic Fatigue Syndrome).


    The abstract reads in part,

    "The authors used the Diagnostic Interview Schedule to assess the lifetime prevalence of psychiatric disorders in 28 patients who met Centers for Disease Control case definition criteria for chronic fatigue syndrome. Compared with studies of the general population and studies of chronically medically ill patients who received the same structured interview, the rates of psychiatric illness in patients with the chronic fatigue syndrome appeared high. An examination of the medical histories of the 28 patients indicated that psychiatric disorders more often preceded the chronic fatigue than followed it."



    This study generated a lot of unfortunate media headlines, thanks to a press release by NIAID titled "Lifetime history of Psychiatric illness in people with chronic fatigue syndrome".
  5. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,025
    Likes:
    439
    Raleigh, NC
    Good question! YEs it could and probably. EBV is passed through the saliva so a little kiss could do it. EBV is so transmissable, in fact, that everybody has it - why some peoiple come down with CFS follow infectious mononucleosis is another matter.
  6. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,025
    Likes:
    439
    Raleigh, NC
    Isn't that something - so that;s another mark he made and I will get that in there. The amazing thing bout that study is that it was such a dinky one. My guess is that the media was ready to run with that finding when it came up and they did.

    I looked -- that was the first psych study anyone ever did on CFS and it was so small and underpowered that it was included i nthe erratum of the Journal it appeared in. I added this to the article

  7. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,025
    Likes:
    439
    Raleigh, NC
    Thanks Enid! Yes, Chia in particular believes you have to identify the bugs and hopefully early on..It'll be interesting to see how that hepatitis drug works out since I think it, spending how patients do on the drug, it should either prove or disprove his theory.

    If they do well (aka AZT) that would really be something.
  8. upnorth

    upnorth

    Messages:
    28
    Likes:
    1
    Canada
    EVB research is interesting to me because Mono either triggered or was the cause of my case of M.E.....but I just can't seem to understand some of it. My M.E. specialist said at a recent appointment that I have a re-activated EBV infection. This seems to be what Montoya treats as well. However, looking at the same test results, I had a regular GP say it was merely evidince of past infection??? Is this just a controversial issue?
  9. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,025
    Likes:
    439
    Raleigh, NC
    You just stepped into one ofthe most controversial areas of CFS. Several ME/CFS physicians (Lerner, Montoya, Dantini) believe that high IgG titers, particularly in older people, are not just signals of a past infeciton - which is how they are general percieved by doctors (that is what they are taught) but are signs of a current infection. These CFS doctors are essentially trying to turn accepted medical knowledge on its head. Its tough being out in front.

    Check out Carols story and the Dantini interview on the front page for more.

    http://forums.phoenixrising.me/cont...g-Fibromyalgia-and-CFS-ME-CFS-with-Antivirals

    http://forums.phoenixrising.me/cont...gue-Syndrome-A-Novel-Author-Returns-to-Health
  10. upnorth

    upnorth

    Messages:
    28
    Likes:
    1
    Canada
    Thanks Cort, this makes a little more sense (now that I've read these articles). I get the feeling that my M.E. specialist is "open" to some of the more experimental treatments, especially if they help patients in practice. But she was quite clear that the EBNA igG being reactive was a sign of past infection and that VCA IgG was a sign of present infection? Is this along the same lines as these other CFS doctors.....the testing didn't even give titers (viral load) which is too bad just because I am curious.
  11. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,025
    Likes:
    439
    Raleigh, NC
    If I have this right she's on board with Lerner et al. on the VCA IgG - if viral loads were 4 times higher normal. I don't know about EBNA IgG.. I had the same problem with one of my few sets of viral test results - no titers! :(
  12. Marlène

    Marlène Senior Member

    Messages:
    441
    Likes:
    210
    Edegem, Belgium
    EBV can be invisible and kill you when combined with corticoids

    Check out this article.
    http://rheumatology.oxfordjournals.org/content/48/11/1462.full


    A patient treated with prednisone was hospitalized with fever. Blood and urine values were normal. Liver enzymes elevated. Liver biopsy was performed and a large B-cell lymphoma was identified. She was treated with rituximab. Her clinical status worsened and she died a few days later.

    Chromogenic in situ hybridization (CISH) detected extensive EBV-encoded RNA (Fig. 1).

    EBV is dangerous.
  13. Hip

    Hip Senior Member

    Messages:
    2,951
    Likes:
    2,785
    A question:

    Above in Cort's article it says: "... there is some unexpected hope on the horizon, though. A hepatitis C drug under development will, he [Chia] believes, be able to knock off the RNA that is causing havoc in ME/CFS. If it does that, that will open the door not only to better treatment but more research."

    Does anyone know which hepatitis C drug under development John Chia is referring to?

    Here is a list of all the hepatitis C drugs under development

    http://www.hcvdrugs.com/

See more popular forum discussions.

Share This Page