Yes, the thing is - how often is the world changed - how often is a field of endeavor changed? Radically altered, so that its hardly even recognizable afterwards? Not very often.......Very rarely, in fact. Most change occur incrementally...if XMRV REALLY works out it will be a extremely rapid paradigm changing event - like the asteroid that hit the planet 100's of millions of years ago that changed almost everything. I actually wonder if any disease has been as altered as quickly as ME/CFS could be if this all works out. The potential is certainly there. We shall see what happens.