The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
Discuss the article on the Forums.

Article from Stanford about ME/CFS 'Immune System Disruption'

Discussion in 'General ME/CFS News' started by aimossy, Oct 21, 2014.

  1. aimossy

    aimossy Senior Member

    Messages:
    1,095
    Likes:
    3,786
    Last edited: Oct 21, 2014
  2. Sasha

    Sasha Fine, thank you

    Messages:
    12,778
    Likes:
    34,182
    UK
    Thanks! Very interesting.

    ..."the primordial soup of creative disruption..." :wide-eyed:

    That's very welcome news - did we know this?

    "There will be blood" :eek:

    Seriously, this is an excellent article - very, very well written. And it looks as though it's in some kind of magazine for Stanford Medicine, so it will be going to a lot of people who we would like to influence.
     
  3. Bob

    Bob

    Messages:
    9,844
    Likes:
    33,946
    England (south coast)
    It's news to me! Well spotted Sasha. Like you say, this is welcome news, if it works!
     
    NK17, Battery Muncher, mango and 8 others like this.
  4. Valentijn

    Valentijn Senior Member

    Messages:
    14,281
    Likes:
    45,812
    Are they going to be inviting Ian Lipkin to resubmit his proposal for a grant, now that the psychobabblers are supposedly not running the review process anymore?
     
    beaker, NK17, Battery Muncher and 5 others like this.
  5. Sidereal

    Sidereal Senior Member

    Messages:
    3,095
    Likes:
    17,172
    Great to see an article like this in a mainstream publication. I would just object to referring to POTS as a "fainting disorder". As far as I'm aware most patients with POTS have never fainted (except maybe on a tilt table). I actually think this is one of the main reasons it's so hard to recognise that we have autonomic disorder. To most docs that just means syncope, the rest is "anxiety".

    LOL - so true. :rofl:
     
    ahimsa, NK17, Ema and 3 others like this.
  6. Sasha

    Sasha Fine, thank you

    Messages:
    12,778
    Likes:
    34,182
    UK
    ahimsa, NK17, Battery Muncher and 5 others like this.
  7. aimossy

    aimossy Senior Member

    Messages:
    1,095
    Likes:
    3,786
    Seems to me that we have some proven quality researchers wanting to work on me/cfs with some big projects now - really hope that people with the illness get backing them with donations and being very loud with NIH about getting them funded. They cant use the excuse now that no one wants to research this illness. We have some ammunition with all this happening.
     
    Last edited: Oct 22, 2014
    NK17, Battery Muncher, Helen and 10 others like this.
  8. snowathlete

    snowathlete

    Messages:
    3,312
    Likes:
    14,610
    UK
    Interpretation may depend on your definition of 'researchers familiar with the condition' though - it getting a mention in this article suggests people with a biological outlook but does anyone know for sure? psychiatrists could fit this definition if you have certain viewpoints.

    Would love to know more specifics.
     
  9. A.B.

    A.B. Senior Member

    Messages:
    3,751
    Likes:
    23,188
    After watching some videos from the ME/CFS Symposion mentioned in the article, again I'm very impressed with Lipkin. At 17:52, he skipped a page about the differences between classical and atypical ME/CFS, saying that it was too complex. Does anyone know what the difference between classical and atypical ME/CFS is? Is it sudden infectious onset vs slow onset? Neurologic or non-neurologic symptoms?

    This page here:
     

    Attached Files:

    Last edited: Oct 21, 2014
    NK17, Valentijn, ukxmrv and 1 other person like this.
  10. Valentijn

    Valentijn Senior Member

    Messages:
    14,281
    Likes:
    45,812
    According to the ICC I think ME can be "atypical" if there's no PEM at all, or if there is PEM but it isn't in response to physical exertion.
     
    NK17 likes this.
  11. Forbin

    Forbin Senior Member

    Messages:
    952
    Likes:
    3,998
    My understanding is that:

    ICC ME requires PENE and at least 7 other symptoms across 3 categories.
    ICC Atypical ME also requires PENE but (as I read it) only requires 5 other symptoms. [I'm not sure if you still need to have at least one symptom from the Energy metabolism/ion transportation category].
    http://www.name-us.org/DefintionsPages/DefinitionsArticles/2012 ICC Primer Short Form.pdf
     
    Last edited: Oct 23, 2014
    NK17 likes this.
  12. Bob

    Bob

    Messages:
    9,844
    Likes:
    33,946
    England (south coast)
    But we don't actually know what Prof Lipkin was referring to when he mentioned atypical ME, do we? He might have had something else specific in mind, other than the ICC. But i think it would be nice if he was referring to the ICC. It seems that he's had a lot of contact with Dr Montoya. Does Dr Montoya ever refer to atypical ME, or frequently use the ICC?
     
    Valentijn likes this.
  13. Forbin

    Forbin Senior Member

    Messages:
    952
    Likes:
    3,998
    It's true; we don't know what Prof. Lipkin was referring to. It could be his own "in-house" brand of atypical ME.

    However, so far, the only other definition of "Atypical ME" that I've seen comes from the 2008 Pediatric Case Definition.
    This definition is only designed for those under 18 year of age.

    http://www.la-press.com/a-case-defi...phalomyelitischronic-f-article-a1147-abstract
     
    Bob likes this.
  14. A.B.

    A.B. Senior Member

    Messages:
    3,751
    Likes:
    23,188
    Comparing adults and children to the same control group doesn't make sense so I doubt this refers to adult vs pediatric ME/CFS.
     
    NK17 likes this.
  15. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

    Messages:
    4,665
    Likes:
    5,480
    :thumbsup::balloons::cool::balloons::)
    :D
     
    NK17 and Bob like this.
  16. ahimsa

    ahimsa Senior Member

    Messages:
    1,844
    Likes:
    4,274
    I'm very slow but finally got around to reading this article (in fact, I'm only halfway through it).

    It's really one of the better articles that I've seen. Thanks so much for posting the link!
     

See more popular forum discussions.

Share This Page