Cort, do we know for sure that WPI did in fact test the CFS samples multiple times but NOT the healthy controls? If this is a confirmed fact, it is a really big pitfall. Remember that one of the contamination theories attempting to explain the disparity between CFS and control samples is that the CFS samples were handled more than the controls. If the CFS samples were in fact handled more, that gives a toehold to the contamination theories (but does not prove it, obviously). Jonathan Stoye is confident in his results too. I love seeing confidence in CFS researchers, but it's not evidence one way or the other. Data data data!