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Lessons from ME/CFS: Finding Meaning in the Suffering
If you're aware of my previous articles here at Phoenix Rising then it's pretty clear that I don't generally spend my time musing upon the philosophy of the disease. I find it better to spend my time reading research and trying my best to break it down to its core elements and write...
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Article: Comedown at CROI: XMRV and CFS at the Conference on Retroviruses and Opportunistic Infectio

Discussion in 'Phoenix Rising Articles' started by Phoenix Rising Team, Mar 7, 2011.

  1. Cort

    Cort Phoenix Rising Founder

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    Raleigh, NC
    Thanks, I was just thinking about going to the video.

    I did see here

    I wonder if they know all the strains used to passage the xenograft?

    Interesting idea about androgen independence. I imagine that it didn't help XMRV - I guess it depends on the efficacy of their tests - which I imagine is quite good - but that is something else to think about.
  2. Guido den Broeder

    Guido den Broeder *****

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    Rotterdam, The Netherlands
    Something to consider. The introduction of nude mice into research laboratories about coincides with the first recorded outbreak of ME (Los Angeles, 1934).

    Although the first official batch is ascribed to Bethesda, Maryland, there was earlier stock. They all seem to orginate from 9 mice brought from Lausanne, Switzerland in 1926 by a Clara Lynch. The trail then goes to Harlan Laboratories that have a site in Placentia, in the Greater Los Angeles Area, but I have no info on when they arrived there (Harlan Laboratories was founded in Indianapolis in 1931 and then quickly expanded.)

    By the way, has XMRV or pre-XMRV been detected in hamsters?
  3. lansbergen

    lansbergen Senior Member

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    I can not find any in vivo tests.

    PubMed gives three hits

    http://www.ncbi.nlm.nih.gov/pubmed/17234809

    An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.

    http://www.ncbi.nlm.nih.gov/pubmed/19811656

    Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor.

    http://www.ncbi.nlm.nih.gov/pubmed/20844050

    Evolution of functional and sequence variants of the mammalian XPR1 receptor for mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV.

  4. Guido den Broeder

    Guido den Broeder *****

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    Rotterdam, The Netherlands
    Thanks, Toos.

    Note that many pet hamsters stem from laboratory hamsters that were introduced during WW II; they quickly became very popular. See http://www.telegraph.co.uk/news/obituaries/4241645/Leonard-Goodwin.html .

    I seem to remember that endemic cases of ME began to get noticed shortly after in the UK.

    What if the lab mice infected the lab hamsters (or perhaps they were already carriers, too)?
    Does pre-XMRV combine to XMRV in hamsters? Pet hamsters often have little defense against infections.
    How many of us had pet hamsters at home? My family had several, when I first got mononucleosis. Three of us later got a disease that has been linked to XMRV.
  5. lansbergen

    lansbergen Senior Member

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    We did not have hamsters or any rodents as pets.

    When I was a kid we had rabbits that were kept for food. There were big wild rats in the barn. Mice were everywhere in rural.

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