It's been interesting because I've been digging into literature about how to produce breakthroughs and they essentially did what the books were talking about; 1.Possibility - The originators created and made real the possibility - working together to biomarker for Alzheimers. Note that a biomarker is not just a diagnostic tool; because its a unique marker for a disorder it gives researchers a direct path to it's origin - so it's a huge focus for research, and, of course, for treatment. 2. Opportunity - As they unfolded the possibility it became clear that working together created an opportunity for everybody. 3. Complete the past and move forward - they 'completed the past' so to speak by ditching old belief systems that got in the way, working together to resolve any issues that remained, forgiving each other and then committing to the future. 4. They created a structure that made it all work - then the rest of it logically followed. It was the first 3 steps - the non-scientific steps - that were the most critical and most difficult.