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Article About CFS and Genetics

Discussion in 'Genetic Testing and SNPs' started by drex13, Jun 11, 2012.

  1. drex13

    drex13 Senior Member

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    I found this report through a link at 23and me. The researchers used 28 specific SNP's to predict CFS with a 76% accuracy. COMT comes up quite a bit. I haven't read through it completely. It looks like it is from 2006. It lists the rs #'s for the SNP's that were used.

    http://www.wicfs-me.org/Pdf Files/Goertzel.pdf
    Gestalt and Hanna like this.
  2. Enid

    Enid Senior Member

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    Interesting - thanks drex - my brother (Doc in the US) went down with ME symptoms not long after me. I'm sure there must be a genetic susceptabilty involved too.
  3. Ever Hopeful

    Ever Hopeful

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    Interesting article- however please take with caution because James Jones of CDC fame was one of the authors!!!
  4. Gamboa

    Gamboa Senior Member

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    What is the date of this study? I couldn't seem to find it.
  5. Gamboa

    Gamboa Senior Member

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    Oh..I see the date is mentioned in the first post-2006.
  6. Ai-Yai

    Ai-Yai Mad Genius

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    Or all is much more simple - i.e. the disease is contagious. And there are a lot of real statistically observed facts which support the last.
  7. Enid

    Enid Senior Member

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    Yes I agree Ai-Yai - still speculation until all the science is in.
  8. Snow Leopard

    Snow Leopard Senior Member

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    It explains why they focused only on discussing the Neuroendocrine related genes. (they also ruled out all sex-linked genes, potentially ruling out a large subset)

    65% sensitivity, 84% specificity is extremely poor. This means that if we were to test 100,000 people, you would have 16,000 false negatives, but only 325 true positives (assuming a prevalence of 0.5%) - eg if you tested positive, you would be 98% sure it was a false positive.
  9. Ai-Yai

    Ai-Yai Mad Genius

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    Well, bc of this point i usually call people who visit various CFS\ME conferences and\or community\group meetings extreem ones. :D

    Unfortunately nowadays a lot of speculation and facts manipulation are present inside science itself.
  10. Enid

    Enid Senior Member

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    Unfortunately always has been with a number of well- known hoaxes over all the years.
  11. Jenny

    Jenny Senior Member

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  12. hopeful2

    hopeful2

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    Hi everyone,

    I'm the one who originally posted this on 23andMe. I've been living with CFS for almost 24 years now. I recently had my DNA analyzed on 23andMe specifically because I was hoping that some day soon they would find some SNPs that were associated with CFS that may help them find both a cause and a cure. I had done a search for CFS SNPs and found this article. It wasn't until after I posted it that I realized that it was an older article.

    I also came across this one http://www.ncbi.nlm.nih.gov/pubmed/21059181 that says that their was a higher frequency of the AA genotype on the rs4680 SNP and at least one C on the rs1042714 SNP for people with CFS. I checked mine and I'm AA on rs4680 and CG on rs1042714.

    I don't know what causes CFS but I do believe there is a genetic component. I think there is something in our genes that makes us susceptible and something in the environment pulls the trigger on that susceptibility.

    Is anybody keeping a list of the different SNPs that have been associated with CFS so far?

    Kathy
  13. Enid

    Enid Senior Member

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    I don't necessarily think it's built in - but more in the likeness of a weakness when the immune system is simply overwhelmed by pathogens. So what tipped my balance at 62 years of age - previously reasonably healthy. Possible susceptabily yes I agree - but the "infections" to my mind need and have all the research going on now ...taint like your ordinary cold as I recall with full blown myalgic encephalomyelitis.
  14. Ai-Yai

    Ai-Yai Mad Genius

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    In general i agree with Enid. From genetic poin of view only predisposition might exist and that is far away not a core quesrtion today.

    CFS\ME is clearly infection and clearly contagious. I for example try to avoid now CFS\ME people and try to have in general very high hygiene standarts. (I'm even not eating at fast-foods or restaurants where other people are eating the same time. I'd rather buy food and eat it at home, in a car or outside. :ninja: )

    But in fact so-called "host-fators" of predisposition for sure include not only genetic component.
  15. Jenny

    Jenny Senior Member

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    What evidence do you have for it being contagious Ai-Yai? I'd be interested in some references.

    Jenny

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