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Article: 2012 - the Year Ahead Pt II: ME/CFS Efforts Expand

Discussion in 'Phoenix Rising Articles' started by Phoenix Rising Team, Feb 22, 2012.

  1. oceanblue

    oceanblue Senior Member

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    UK
    Thanks for those additional quotes. And it's worth remembering that you'd get a 50% classifier rate by tossing a coin!

    I think failure to replicate the initial findings on an independent sample is a common failing for CFS research, particularly where biomarkers are postulated. With a single sample, thresholds are set to maximise the preidctive power for that particular set of patients and controls, which is 'overfitting' data. This from Wikipedia explains the issue:
  2. Cort

    Cort Phoenix Rising Founder

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    It's astonishing how off they were. Those genes had almost no predictive value - and they appeared to have been validated at least once. Almost 60% of CFS patients were classified as healthy controls - ouch....Its kind of mind-boggling.
  3. MishMash

    MishMash *****

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    Georgia
    Haven't we been thru this with florinef? Can anybody raise their hand and say "this drug helped my ME/CFS symptoms"? I mean on a long term basis? I went thru all the tilt table stuff and actually spoke with Dr. Rowe afterwards. He is a consummate gentleman, a first rate researcher and medical practioner, and he really cares about ME/CFS patients; but this theory that taking IO negating drugs are helpful, in ME/CFS, is totally wrong.

    As Mitt Romney says, I'll bet $10,000, or one of my wife's two Cadillacs, or or.....
  4. Cort

    Cort Phoenix Rising Founder

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    This is a great question (and a poll would be good).. the study said no but Dr. Rowe regrets that study because he was and is still using Florinef to good effect in some (lucky) patients. ME/CFS is such a diverse field - one of the CAA's studies is looking at 3 different ways to affect blood flows. I imagine they will find that each of them is effective in some patients (achhh!!!).

    Rowe just did a small study which showed that fludrocortizone (is Florinef) is effective in relieving nausea in a portion of OI patients.

    Abstract
    INTRODUCTION/RESULTS: In 17 patients, chronic idiopathic nausea was associated with orthostatic intolerance (OI) by abnormal tilt table tests (88%) or gastric dysrhythmias (71%). After fludrocortisone treatment, there was >26% nausea improvement in 71%, 1-25% in 6%, and no improvement in 24%. In six subjects, EGGs repeated after >50% nausea improvement all remained to be abnormal, suggesting nausea is independent of gastric dysrhythmias. CONCLUSION: Association of EGG abnormalities and OI in this subset of nausea patients suggests a generalized disturbance of autonomic regulation.
  5. Ema

    Ema Senior Member

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    Midwest USA
    snowathlete and Valentijn like this.

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