Hi all, I'm generally a lurker here but have been looking at the methylation question lately. I've received a lot of conflicting advice in another forum about whether or not the genetic profile of methylation impairment is even clinically significant. I do have some mutations that would affect my methylation cycle but I'm not really sure what to think anymore. Since, to me, the proof is in the pudding, maybe it's useful for me to hear some success stories. My own genetic issues are primarily with CBS upregulation and then a more minor heterozygous mutation in MTHFR. If the recommended test strips are to be believed, I do have high sulfate levels (between 800 and 1200). The diet / protocol for reducing sulfur is complicated and difficult-- never mind that there is a low-sulfur version and a low-thiol version with radically different recommended foods-- and if I'm chasing rainbows I'd prefer not to make the effort. On the other hand, after 30 years living with this, it would be nice to have the ability to do something to make myself feel better, even if it's a long slog. So, help me understand. Did this approach make you feel better over the long haul? If you had CBS upregulation, was it worth the effort of eating to the protocol? Or is it, as has been suggested, junk science where just about everyone has these mutations? I'm truly not trying to start argument here, just wanting your success stories if you have them, as I'm so tired of being tired. I've heard the negatives, so mainly looking for the positives if they are out there. Thanks much for your help.