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There has been some speculation on the forums that MTRR/MTR mutations are more important than some of are giving them credit for.
Perhaps they are a major contributor to B12 deficiencies and a large need for the active B12 supplementation.
I have observed that some on the forum can not tolerate methylfolate without taking high doses of methyl B12, possibly because of a methyl trap due to MTRR/MTR mutations?
Any thought, opinions or experiences?
Perhaps they are a major contributor to B12 deficiencies and a large need for the active B12 supplementation.
I have observed that some on the forum can not tolerate methylfolate without taking high doses of methyl B12, possibly because of a methyl trap due to MTRR/MTR mutations?
Any thought, opinions or experiences?