It seems to be all happening on the research front, with lots of excitement about metabolomics in particular, but as someone who is definitely not a bio-boffin, I can't tell if there's convergence on the cause of our illness. I remember @Rose49 saying how excited Ron Davis was at the IiME conference that lots of people seemed to be thinking along the same lines, but maybe I'm reading too much into that statement! So, are there any elements of the mechanism of our disease(s) that are agreed on? Are we close to a "unified theory"? If we're not, what's needed to get us there, is that research already underway, and when can we expect it to be reported? Tagging @Simon, @znahle, @Jonathan Edwards, @ChrisArmstrong in case interested.