Hi, I found and interesting article about new research showing that depressed patients have low ATP- due to mitochondrial dysfunction. Unfortunately it's only in german and I'm too tied to translate the full article. You might use Google translator. Link http://www.fr-online.de/wissenschaf...ellen-die-energie-fehlt,1472788,28125602.html I understand how many of cfs patients get defensive when called depressed, because of the misconception that depression is just a "mental" thing not knowing how much of our mental as well as physical state is connected to chemicals. Trying to treat this with speech therapy is like treating heart disease with it. in case of endogenous depression it's the body that's causing the physical and mental state of depressed patients that is very often related in some points to cfs. Just my 5 cents. In my sig link you can see that cfs often have low neurotransmitter to begin with. You can call it comorbid. Many chronic heavy depressed patients have partially cfs symptoms and vice versa. In both cases my wish is that the population and professionals acknowledge that IT IS PHYSICAL and treat accordingly.