The points below run the risk of being a little obscure to some of you, but this issue strikes me as one that should be among the top three discussions in a CFS forum. Yet, no one here is discussing this. No one is experimenting with Niagen. How can this be? Read point number one of 10 by James Watson in this article: http://www.anti-agingfirewalls.com/...list-of-things-i-learned-about-aging-in-2013/ The number one anti-aging story of 2013 was that "...mitochondrial dysfunction and...Warburg-type metabolism are fully reversible with the supplementation of NAD+ precursors." Cancer is the ultimate expression of a cell that is fueled by glucose, and does not need mitochondria. CFS is similar however, because somehow the mitochondria are not functioning well, and the cell is being forced to rely on glucose metabolism. Because that is inefficient, many metabolic processes run out of energy. Cancer is a special case because the mitochondria get permanently damaged and basically the cell takes on a metabolism that no longer needs mitochondria. But CFS involves cells with mitochondria that are still intact. In theory, CFS might respond very well to the generation of more NAD+. This is the key point. By whatever means (still not determined), the cells of the CFS sufferer are relying on glucose metabolism, and insufficient NAD+ is produced. Insufficient NAD+ means insufficient ATP production. Insufficient ATP means many cellular processes run too slowly to be effective. What is exciting about the Watson article is that he is saying we may have chemical ways to reverse this NOW. Watson points out that there are two precursors to NAD+ 1) A precursor that is one step away from NAD+ named NMN, but this is very expensive and not available. 2) A precursor that is two steps away from NAD+ named Nicotinamide Riboside (NR). Proprietary name is Niagen. I found a supplier online and it is not cheap, but if it works who wouldn't pay it? Watson quotes a study by David Sinclair at Harvard in which mice were given NMN, and all of their age-related defects in NAD+ production reversed, quickly. He points out that there are no experiments with Niagen, but he wonders if this won't have the same effect. Questions: 1) Have any of you experimented with Niagen / NR, and what was the result? 2) What is the recommended dose for a CFS sufferer? Does it need to be spread out over the day, to support metabolism continuously, or can the body buffer a single dose? 3) Is it necessary to take NR together with other specific vitamins, in order to prevent other B vitamins to be dysregulated? 4) Is there any way to profile our blood cell profile of NAD+, NADH, and the levels of chemicals and enzymes in the pathway(s) that create NAD+? I see NR / Niagen mentioned in only a few threads here. I'm shocked that this isn't a much bigger topic. This holds out potential to be a cure.