A New Decade of ME Research: The 11th Invest in ME International ME Conference 2016
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Anyone tried SAMe who have CBS upregulation?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Bdeep86, Jul 29, 2013.

  1. Bdeep86

    Bdeep86 Senior Member

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    I am needing a methylation shortcut, and I have issues with acetylcholine and cortisol so its hard for me to use the choline based recommendations. However, I have bad issues with CBS, I have heard that SAM can effect CBS doesn't anyone know if SAMe supplements aggravate CBS issues?
     
  2. caledonia

    caledonia

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    Cincinnati, OH, USA
  3. Bdeep86

    Bdeep86 Senior Member

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    TMG seems to give me low cortisol symptoms and I don't feel that great on it so I am thinking to try some SAMe
     
  4. UM MAN

    UM MAN Senior Member

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    I take 200mg of SAMe around 8pm. I feel like it improved my sleep.
    400mg of SAMe interfered with my getting to sleep. I'm a freak..
     
  5. ahmo

    ahmo Senior Member

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    Bdeep86, I had reactions to both SAMe and NAC before I knew anything about CBS and sulfur issues, or about methylation. Both of these supps were excitotoxins for me. ahmo
     
  6. Critterina

    Critterina Senior Member

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    ahmo,
    Do you mind saying what kind of reactions? I'm trying to figure out what symptoms go with what problems. I've been on Me, NAC, and ALA up until finding I'm CBS.
     
  7. ahmo

    ahmo Senior Member

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    At that time I got very twitchy, anxious/agitated. And I see now that I was already overflowing with thiols. These days when I get too much sulfur I have an eczema flare.
     
  8. Critterina

    Critterina Senior Member

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    Thanks. I got the eczema flare, too, every time I drank red wine. And recently, too, after 3 months of Me and NAC. Not twitchy, though. Liver area has been achier and belly slightly distended; I was trying to pin that to sulfur. Maybe not.
     
  9. Skyline

    Skyline Senior Member

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    I'm hetero CBS and SAMe has been an important piece for me. I take 400mg in morning now.
     
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