1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
9th Invest in ME International ME Conference, 2014 - Part 2: Pathogens and the Gut
Mark Berry continues his series of articles on the 9th Invest in ME International ME Conference in London, with the emphasis shifting from autoimmunity to pathogens and the gut ...
Discuss the article on the Forums.

Anyone tried SAMe who have CBS upregulation?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Bdeep86, Jul 29, 2013.

  1. Bdeep86

    Bdeep86

    Messages:
    53
    Likes:
    4
    I am needing a methylation shortcut, and I have issues with acetylcholine and cortisol so its hard for me to use the choline based recommendations. However, I have bad issues with CBS, I have heard that SAM can effect CBS doesn't anyone know if SAMe supplements aggravate CBS issues?
     
  2. caledonia

    caledonia

    Messages:
    2,985
    Likes:
    1,601
    Cincinnati, OH, USA
  3. Bdeep86

    Bdeep86

    Messages:
    53
    Likes:
    4
    TMG seems to give me low cortisol symptoms and I don't feel that great on it so I am thinking to try some SAMe
     
  4. UM MAN

    UM MAN

    Messages:
    95
    Likes:
    19
    Florida
    I take 200mg of SAMe around 8pm. I feel like it improved my sleep.
    400mg of SAMe interfered with my getting to sleep. I'm a freak..
     
  5. ahmo

    ahmo Senior Member

    Messages:
    1,322
    Likes:
    909
    Northcoast NSW, Australia
    Bdeep86, I had reactions to both SAMe and NAC before I knew anything about CBS and sulfur issues, or about methylation. Both of these supps were excitotoxins for me. ahmo
     
  6. Critterina

    Critterina Senior Member

    Messages:
    788
    Likes:
    353
    Arizona, USA
    ahmo,
    Do you mind saying what kind of reactions? I'm trying to figure out what symptoms go with what problems. I've been on Me, NAC, and ALA up until finding I'm CBS.
     
  7. ahmo

    ahmo Senior Member

    Messages:
    1,322
    Likes:
    909
    Northcoast NSW, Australia
    At that time I got very twitchy, anxious/agitated. And I see now that I was already overflowing with thiols. These days when I get too much sulfur I have an eczema flare.
     
  8. Critterina

    Critterina Senior Member

    Messages:
    788
    Likes:
    353
    Arizona, USA
    Thanks. I got the eczema flare, too, every time I drank red wine. And recently, too, after 3 months of Me and NAC. Not twitchy, though. Liver area has been achier and belly slightly distended; I was trying to pin that to sulfur. Maybe not.
     
  9. Skyline

    Skyline Senior Member

    Messages:
    132
    Likes:
    72
    Bangkok, Thailand
    I'm hetero CBS and SAMe has been an important piece for me. I take 400mg in morning now.
     
    Critterina likes this.

See more popular forum discussions.

Share This Page