Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Anyone tried Risperidone?

Discussion in 'General Treatment' started by Bdeep86, Jun 23, 2015.

  1. Bdeep86

    Bdeep86 Senior Member

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    Saw a couple anecdotal reports of this (and amisulpride) helping people. I got a script for it and about 5 minutes ago just tried a quarter of .5mg. I know you have to hit a sweet spot with this medication, just wondering if anyone has tried it before. Also pretty concerned about weight gain but i'm not sure that that can happen at the much much smaller doses. Thanks for any feedback.
     
  2. A.B.

    A.B. Senior Member

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    My impression is that research generally indicates low dopamine levels in CFS patients. An antipsychotic such as Risperidone will reduce these further. I'm also curious why anyone would use a sedating medication for CFS. The illness is characterized by reduced energy levels - it makes no sense to try and reduce them further.
     
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  3. Bdeep86

    Bdeep86 Senior Member

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    When you use these medications at a low dosage it actually increases dopamine and seratonin.
     
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  4. minkeygirl

    minkeygirl But I Look So Good.

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    I have it for sleep. I haven't used it lately though when I did I took a really low dose. I've read about the weight gain too. I don't know if a low dose matters.

    If you feel like eating everything in sight then stop. And monitor your weight. I know with Lyrica some said no matter what they did they gained weight.
     
  5. AaroninOregon

    AaroninOregon noob

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    Hippietown

    For insomnia perhaps??
     
  6. Grigor

    Grigor Senior Member

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    A friend is using Rispedone and has amazing results on his ME.
    So very curious about it myself.
    It does seem to help with neuroinflammation.
     
  7. Hip

    Hip Senior Member

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  8. Grigor

    Grigor Senior Member

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    Thank you. Very informative the other thread. Long posts haha. Can't handle all the text but saw some good stuff.

    Also considering the Nitroglycerin
     
  9. Grigor

    Grigor Senior Member

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    @Hip, as it raises dopamine. Could it be depleting dopamine and well? Like with Parkinson. With L Dopa??
    ME and Fibro are linked to lower dopamine. Right??
     
  10. Hip

    Hip Senior Member

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    Could you explain what you saying in more detail please; I am not following.
     
  11. Grigor

    Grigor Senior Member

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    @Hip was referring to this.

    ME patients and Fibro seem to have low dopamine. Or might. So when upping the dopamine it could also deplete dopamine reserves like in Parkinson with L Dopa ?? And once that happens then you're in big trouble?
     
    Last edited: May 12, 2016
  12. Hip

    Hip Senior Member

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    Dopamine is synthesized when needed, so I don't think there are any reserves to deplete.

    Very low dose amisulpride (12.5 mg to 200 mg) does not actually increase dopamine levels, but rather activates the dopamine receptors, so this is like having elevated dopamine levels.

    But higher doses of amisulpride do the reverse, and inhibit dopamine receptors.

    If find 12.5 mg daily of amisulpride useful for several of my ME/CFS symptoms. Very low dose amisulpride activates the dopamine D2 and D3 receptors.

    Activation of the D2 receptor on astrocytes has been shown to reduce neuroinflammation.

    5% of ME/CFS were found to have autoantibodies to the dopamine D1 receptor, which will affect dopaminergic functioning.



    To boost the dopaminergic system, you can either raise dopamine, activate (agonize) dopamine receptors, or you can take supplements or drugs like uridine or amantadine that actually create new dopamine receptors in the brain.

    I posted a list of dopaminergic drugs and supplements here.

    I'd really like to find a drug that activates the dopamine D1 receptor, as this is associated with pleasure and reward, and I suffer from anhedonia (= lack of feeling pleasure and reward).
     
  13. Grigor

    Grigor Senior Member

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    Thank you for your response. Will check it out. Super
     
  14. sflorence

    sflorence Senior Member

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    Hi Hip!

    Just started this drug @ .5mg today, will keep this forum updated.

    The second link doesn't work, any clue to why that is?

    Also, I find it interesting how a lady posts her fatigue recovery story and everyone just ignores it LOL.... Zero responses on her post...

    Side note: I have spoken to 2 people who have CURED their MCS from risperdal.
     
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  15. Hip

    Hip Senior Member

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    The website domain (http://forum.notcrazy.net) appears to be either temporarily down or no longer in existence.
     
  16. sflorence

    sflorence Senior Member

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    Reporting back. Tried Risperdal at .5mg the first day and 1mg the next.

    Nothing happened besides getting more lethargic/tired.

    I am going to try .25mg next, but currently am experimenting with something else.
    I read from that post that she felt good at .5 but not 1. So maybe I need to find my sweet spot.
     

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