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Anyone taking PS or TMG?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by tim0011, Jun 3, 2013.

  1. tim0011

    tim0011

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    I've been doing PS 100mg and TMG 1000mg per day in past few days. I took my TMG with dinner and my PS right before bed time but they were causing really bad nightmares and very restless sleep.

    When do you think is the best time taking these 2 supplements? Has anyone tried them?
  2. xjhuez

    xjhuez Senior Member

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    I take a small 300mg dose of TMG in the morning. I think taking a full dose was pushing me into overmethylation, as it sometimes made me feel anxious and jittery.
    L'engle likes this.
  3. tim0011

    tim0011

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    Do you take it with the meal or before a meal? We have very similar SNPs though! I'm also totally jammed at BHMT and also have both CBS genes so I'm trying to decrease my sulfates by opening up my BHMT route with TMG and PS.
  4. xjhuez

    xjhuez Senior Member

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    I take TMG crystals dissolved in water about 30mins before breakfast. I've never tried PS.

    I haven't gotten to working on sulfates yet. I should buy some test strips, I suppose.
  5. tim0011

    tim0011

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    Yes, you would need test strips for measuring sulfate levels. I have Quantofix sulfate strips, I ordered them from CTL scientific but also Amazon has them. You get 100 strips.
  6. Lotus97

    Lotus97 Senior Member

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    I have 3 BHMT +/+ too, but I'm also COMT +/+ so I'm not sure what to do.
  7. vamah

    vamah Senior Member

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    I take PS 100 in the evening because it is supposed to lower cortisol levels. Don't know if it's helping, but it isn't hurting.
  8. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

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    What vamah said.
  9. L'engle

    L'engle moderate ME

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    I stopped taking TMG yesterday and felt better. I was in injsatiable hypokalemia the last few weeks and while I don't the TMG caused it I think it had to be taken out to return things to normal.
  10. tim0011

    tim0011

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    So you're saying that PS is supposed to be taken in the evening? Away from food or with food?
  11. vamah

    vamah Senior Member

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    I don't find any difference for me. Just because of the time of day, I usually don't take with food.
  12. Lotus97

    Lotus97 Senior Member

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    With the amount of methylcobalamin you're taking (15+ mg if I remember correctly), you probably have plenty of methyl groups and SAMe already. Adding TMG is probably just overkill.
  13. L'engle

    L'engle moderate ME

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    Yeah I've had to ramp it way down, at lest for the enzymatic therapy. I take 5mg of that now alternating with 45mg AOR. The AOr doesn't cause overdrive/extreme hypokalemia. I think the the enzymatic therapy is a different thing altogether and the mg to mg ratio between it and other brands is not remotely comparable.
  14. Lotus97

    Lotus97 Senior Member

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    Am reading it right that you consider 5 mg Enzymatic Therapy equivalent to 45 mg of AOR? I know Enzymatic Therapy is supposed to be one of the best, but still...I'm in the process of comparing brands of methylcobalamin so I'm curious. I assumed AOR was at least decent compared to the other brands. Have you tried Solgar or Bluebonnet by any chance?
  15. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Make sure your ps doesnt have any or too much phosphatidyl choline as this can be stimulating. Some brands contain this and others contain alot. I buy bulk powders and cap ps myself. Label doesnt sat it contains any choline.
  16. Lotus97

    Lotus97 Senior Member

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    dbkita said when the BHMT gets stimulated, a greater amount of dopamine is converted into norepinephrine. Phosphatidylserine (and Seriphos which is a more potent form of PS), choline, phosphatidylcholine, TMG, and betaine hcl (same as TMG) all stimulate the BHMT pathway.

    Methylation can also increase catecholamines (dopamine, norepinephrine, and epinephrine).

    Also, increasing acetylcholine (either with choline or phosphatidyl choline) can cause anxiety. There's more info about acetylcholine in this thread:
    http://forums.phoenixrising.me/inde...acetylcholine-toxicity-the-cause-of-cfs.9757/
    heapsreal likes this.
  17. L'engle

    L'engle moderate ME

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    Lotus, The brands of b12 seem to be just different without a linear relation between them. AOR is a decent brand but it's not the same as enzymatic therapy. It doesn't seem to cause the runaway low potassium problem. It's probably about on par with solgar which I tried two years afo, but it's available in stores here. I haven't tried bluebonnet.
    Lotus97 likes this.
  18. Lotus97

    Lotus97 Senior Member

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    Ok, thanks. So why do you take two separate brands then if Enzymatic Therapy is so much better? I'm switching to methylcobalamin and trying to figure out what to do. I tried Swanson vs. Enzymatic taking 5 times as much Swanson. I felt sort of sickish the days I took 5 mg and 7.5 mg of Swanson, but not when I took 1 mg or 1.5 mg of Enzymatic. I don't know if the bad feeling was from overmethylation or just a side effect of that brand. I remember Lou saying something about Webber giving him a headache, but not doing much else besides that. Solgar is on my list of brands to try too. I'm considering Webber although I've heard from 3 different people who said it did nothing. Someone told me Source Naturals was good, but they're sensitive so I'm not sure how accurate their experience is.
  19. L'engle

    L'engle moderate ME

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    I think you might want to start on small amounts of any brand and then find out what you can tolerate of each. I take more than one brand because several of us found that using just one brand day after day led to decreased effectiveness of the brand. This happened to me with AOR, otherwise the effectiveness of the brand just decreased, as people are saying happened with jarrow.
    Lotus97 likes this.
  20. triffid113

    triffid113 Day of the Square Peg

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    Me too. I also have 3 BHMT and COMT +/+ and COMT +/-. I take 2g TMG in divided doses with meals. The only things I do not take with meals are my hormone pills and antioxidants. Everything else could potentially hurt my stomach so I only take with food. I try to take my hormones and antioxidants when I first get up on an empty stomach, then the bulk of my pills at breakfast, then the few I take in divided dose I take later at lunch or dinner.

    I don't take PS because it didn't seem to do anything for me. However I read this in Iron Man Magazine Feb 2013 about PS:

    Researchers state that Ps can be used as a natural substitute for anabolic steroids.

    The article says that cortisol is a muscle-melting hormone that floods your blood stream when you're stressd, such as when working out. This is why so many body builders who want to bulk up resort to steroids as tey partially block cortisol. Steroids bind with glucocorticoid cell receptors, those that interact with cortisol, and that tilts the balance away from muscle melting. [Hmm. Coffee = liquid cortisol. Also, DHEA is a steroid].

    Studies show that PS taken orally can decrease cortisol 30%. There is even a book: Phosphatidylserine: Promise for Athletic Performance, by Edmund Burke PhD and Thomas Fahey Ed., D. They say that PS depressed cortisol production, while anabolic steroids block the action of cortisol by cross-linking with the cortico-steroid receptor site.

    PS is entirely natural. It is a soy lipid often given to seniors to prevent muscle and brain degeneration.

    As a result of PS lowering cortisol:

    Lower cortisol levels have been shown to produce an increase in free testosterone and the more free t, the easier to build muscle. [More free t most likely means less DHT fyi]

    PS has been shown to improve mental sharpness and focus.

    Less cortisol reduces carb cravings and helps you drop fat. [This resonates...I have long learned that coffee increases carb cravings for me]

    It makes me want to try PS again. The article does not discuss dose. The article is actually an ad for PS and the dose is presumably what they put in their supplement...

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