I switched from the Yasko Neurological Health Formula multi to the Thorne about 2 weeks ago when Rich posted his thoughts about a possible change in his protocol. I had been on Rich's protocol for a little over a year and was doing pretty well on it. I do remember a few rough days when I added in the folates but it finally smoothed out. Right away after starting the Thorne I became very gloomy. I don't know if my body is missing something that was in the Yasko but not in the Thorne or if something in the Thorne does not agree with me. I have had a couple of good days but mostly mild depression. I'm trying to hang with it just in case I am going through a period of adjustment. I am taking 2 a day just like with the Yasko multi. What are others experiencing from the change in the multi? Anyone familiar with both multi's have any ideas about my reaction?