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Anyone familiar with the IgA snps? Got some +/+

Discussion in 'Genetic Testing and SNPs' started by AkeBono, Jan 23, 2015.

  1. AkeBono

    AkeBono

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    Are they really important?
    do they have a role in the neverending gut and ENT infections?
    Dont want to overlook them but neither to make them too important if they are not.
    Any input is appreciated.thanks

    upload_2015-1-23_18-39-38.png
     
    roxie60 likes this.
  2. Aurator

    Aurator Senior Member

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    Are you IgA deficient? Are you saying you yourself have never-ending gut and ENT infections?
     
  3. AkeBono

    AkeBono

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    I am yes. Both blood and SigA. And yes also to the second question.
    What I wanted to find out is do these snps really influence my body function?
    So that I easily catch / develop infections?
    Or is it the chronic infections that lowers the IgA.
     
  4. Sea

    Sea Senior Member

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    I have IgA deficiency. I don't think chronic infections lower IgA, it's the other way around. Low IgA predisposes to infections.

    Rs9275224 AA 20%. I am AA
    Rs2856717 homozygous AA ranges from 1% to 18% depending on ethnicity. I am AG
    Rs9275596 homozygous CC ranges from 4% to 14%. I am CT
    Rs9357155 homozygous AA is 1% to 4%. I am GG

    Rs2412971 overall minor allele frequency is 44%. I am GG
    Rs4728142 overall minor allele frquency is 29%. I am AG. This snp has reference to more research in OMIM from dbsnp. It has some association with SLE (lupus).

    I can't see any reference to research about IgA deficiency from these snps.

    This research
    http://www.nature.com/srep/2014/140509/srep04904/fig_tab/srep04904_T1.html
    suggests that the minor alleles of rs9275224, rs2856717, rs9275596 and rs2412971 are actually protective against IgA nephropathy
     
    Valentijn likes this.
  5. AkeBono

    AkeBono

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    Thank you for your answer Sea!.
    Can you tell what do you do / did you do about that low IgA?
    Ive read colostrum can help but I'm intolerant to dairy.
     
  6. Sea

    Sea Senior Member

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    NSW Australia
    I know that some get IVIG, but it is not something my doctors have shown any interest in treating. Mine was only tested as an aside really when I was being tested for Celiac antibodies, because a negative antibody test for Celiac is irrelevant if you are IgA deficient.

    Criteria for being treated with IVIG varies in different countries. In Australia you have to have a number of documented infections per year and I think deficiencies in IgG as well as IgA
     
    butterfly me likes this.
  7. AkeBono

    AkeBono

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    oh, i thought there is something i can do by myself for that...
    doctors here are neither open nor willing to treat / improve that as is not a problem?
     

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