I have been suffering from severe insomnia for the past 10 years (40 year old male). I can usually fall asleep, but wake within 1-2 hours and usually stay awake the rest of the night (or get another hour of sleep around 4am). I have been through hundreds of labs, drugs, supplements and therapies but haven't found a solid answer yet. The only nugget I have right now is elevated whole blood histamine (142 on a scale of 12-127). On a prior test it was 151, so I know this has been a real issue. This can indicate "undermethylation", and it makes sense that it would cause insomnia because calming neurotransmitters are low, while stimulating histamine is high. I am waiting for the results of another test, Methylation Pathways Panel, that will truly show if I am undermethylated. I have been taking methionine 2g in divided doses, with vitamin C for several months. I have seen some improvement, but nothing spectacular. Taking too many "methyl" donors gets me too wired up, so it is a balancing act. Anyone else in the same boat here?