Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
Discuss the article on the Forums.

Anyone else have rs880844 AA?

Discussion in 'Genetic Testing and SNPs' started by Kimsie, Dec 9, 2014.

  1. Kimsie

    Kimsie Senior Member

    Messages:
    397
    Likes:
    407
  2. Critterina

    Critterina Senior Member

    Messages:
    1,202
    Likes:
    700
    Arizona, USA
    Nope, I've got the GG.
     
  3. halcyon

    halcyon Senior Member

    Messages:
    2,292
    Likes:
    5,365
    AG here. Not seeing a lot about it on Google. What's your interest in it?
     
  4. Valentijn

    Valentijn Senior Member

    Messages:
    14,281
    Likes:
    45,811
    It doesn't mean anything just because it's less frequent. And in the case of that SNP, the AA genotype is still extremely common (up to 30% in some populations), just slightly less common than GG or AG. It also doesn't have any known mutation in the protein associated with it, nor any research showing that it's a problem.
     
  5. Kimsie

    Kimsie Senior Member

    Messages:
    397
    Likes:
    407
    I see. On opensnp it was 5%, but that is probably not a very large sample.

    Halcyon, I was asking because I think there could be something going wrong with the iron-sulfur clusters, which would cause the electron transport chain to be inhibited, but there wouldn't necessarily have to be a mutation for that to happen.

    I think the electron transport chain must to be inhibited in these illnesses, and I was wondering if there are some people who are more susceptible to inhibition of the ETC by interference with iron-sulfur clusters (by H2O2, i.e. oxidative stress) than other people.
     
    halcyon likes this.

See more popular forum discussions.

Share This Page