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Anyone else have a massive improvement from Tyrosine?

Discussion in 'General Treatment' started by drob31, Sep 27, 2017.

  1. drob31

    drob31 Senior Member

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    It seems to cut through brain fog and fatigue like a knife through butter. I have to wonder if it's possible to be tyrosine deficient if you have malabsorption issues?

    Could it be modulating the immune system somehow?
     
  2. Billt

    Billt Senior Member

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    Never tried it . But sounds like it is working for you
     
  3. drob31

    drob31 Senior Member

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    I think it's part of a few other things including diet, but I would love to know the mechanism. It also boosts thyroid.
     
  4. Billt

    Billt Senior Member

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    These are the 2 Huge factors in my sons health. Would be great if this could help
     
  5. drob31

    drob31 Senior Member

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    You mean diet and thyroid?

    I've learned a bit about tyrosine, by experimenting, and more is not always better, also it may or may not need to be pulsed.
     
  6. Billt

    Billt Senior Member

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    Sorry brain fog and fatigue .. Have not found anything to improve this
     
  7. drob31

    drob31 Senior Member

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    You could try 250 mg of tyrosine on an empty stomach 30 min before food in the morning. You should know within an hour.
     
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  8. Billt

    Billt Senior Member

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    Worth a try and would know pretty quick
     
  9. Mij

    Mij Senior Member

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    Tyrosine and Phenylalanine were the lowest on my amino acid panel, but when I supplemented with Tyrosine I felt a bit hyper.

    Phenylalanine converts to Tyrosine. Perhaps I should have taken Phenylalanine instead to see how that works out.
     
  10. Tammy

    Tammy Senior Member

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    Phenylalanine brought me out of a deep depression years ago.
     
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  11. ljimbo423

    ljimbo423 Senior Member

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    I have been taking tyrosine for several years, daily. I started taking L-tyrosine and it helped noticeably. Then I tried N-acety-tyrosine and it gave me a much stronger effect, at a much lower dose.

    The type that works best for someone seems to be very individual though. If I take too much, I get too hyper and have trouble sleeping. The boost it gives in dopamine seems to be why it helps me so much.

    I also think it would probably work better pulsed but it is so important to my clarity of mind, I don't want to stop it even for a day. If I did I'd probably feel like I was sleep walking all the time.;)

    Jim
     
  12. Isaiah 58:11

    Isaiah 58:11

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    I was tyrosine deficient on a test. I tried a bottle and didn't seem to notice anything but I was doing a lot of different things at that point. I just ordered a higher quality tyrosine last week but I can't remember how much I had been told to take. What dosage has been working for you all?

    @Tammy interesting on the phenylalanine. I drink coffee like mad but it never makes me feel like diet coke used to! If only diet sodas didn't contribute to insulin resistance... Maybe I need a side of phenylalanine with my coffee? Do you suppose it was the phenylalanine itself or the downstream tyrosine that helped. How much did you take?
     
  13. Alvin2

    Alvin2 If humans were rational...

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    Had no effect on me, though it was years ago i tried it
     
  14. Tammy

    Tammy Senior Member

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    My guess is it was the downstream tyrosine that helped. Sorry I don't remember how much I took but my body was pretty sensitive so if I had to take a guess..........I probably took a conservative dose.
     
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  15. andyguitar

    andyguitar Senior Member

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    It's a very tricky thing to reach a conclusion about. There is a possiblity that some of the theraputic effects of tyrosine and phenylalanine is caused by the effect they have on tryptophan. But like i say it's hard to reach a conclusion about these things. But hey if it works do it!
     
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  16. Chocolove

    Chocolove Tournament of the Phoenix - Rise Again

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    @drob31 I too got a fairly immediate hit from Tyrosine. If you try amino acids on your tongue you will usually respond within 10 minutes if it will affect you. It amped me up pretty good. However that pushed my poor functioning adrenals into a crash. I hope you are not headed for a crash and further damage. If you are feeling tired it would be wise to avoid this stimulant which could push you too far. Tread with caution.

    Phenylalanine and tyrosine are precursors to the body's three "fight or flight" hormones, dopamine, epinephrine (adrenaline) and norepinephrine.
    Phenylalanine---converts to--->Tyrosine---converts to--->DOPA---converts to--->Dopamine
    Independent Supportive Research:
    University of Nebraska at Lincoln
    Indiana State University
    Rensselaer Polytechnic Institute

    Unfortunately it is not always the fix to supply what is missing to feel good. One can overload a system that the body has down-regulated because it cannot handle the load...something else may be in need of repair.

    Julia Ross published a book on using amino acids for mood as certain amino acids are precursors to certain neurotransmitters and thus affect neurotransmitter deficiency. She posted a questionnaire which can help you figure out which amino acids might affect you. It certainly gives you a clue as too how your system is operating. See: http://moodcure.com/take_the_mood_type_questionnaire.html
    This article may also be of interest: https://nootriment.com/l-tyrosine-for-anxiety/

    "Tyrosine is a precursor to neurotransmitters and hormones
    In dopaminergic cells in the brain, tyrosine is converted to L-DOPA by the enzyme tyrosine hydroxylase (TH). TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine can then be converted into other catecholamines, such as norepinephrine (noradrenaline) and epinephrine (adrenaline).
    The thyroid hormones triiodothyronine (T3) and thyroxine (T4) in the colloid of the thyroid also are derived from tyrosine.
    Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine),[15] but has little if any effect on mood in normal subjects.[16][17][18]" https://en.wikipedia.org/wiki/Tyrosine

    "It's rare to be deficient in tyrosine. Low levels have been associated with low blood pressure, low body temperature, and an underactive thyroid. This does not mean, however, that taking tyrosine supplements will help any of these conditions."
    http://www.umm.edu/health/medical/altmed/supplement/tyrosine

    [PDF]Neurotransmitter Deficiency and Cortisol Excess - The Mood Cure
    https://www.moodcure.com/pdfs/Townsend-Letter-NNTI article.docx.pdf
    ... in response to a T.L. article, “The Cortisol-Sleep ... and well to neurotransmitter precursors such as GABA, tryptophan, and/or melatonin. Others .... exacerbated by the use of the stimulating amino acid, l-tyrosine.

    Repletion and balancing of amino acids:
    https://www.drlam.com/blog/brain-boosting-supplements-and-afs-part-5/11234/
    https://www.drlam.com/blog/biological-rhythm-disruptions-and-adrenal-fatigue-syndrome-part-2/11319/

    http://amino-acid-therapy.com/neurotransmitters/proper-neurotransmitter-balance/

    http://www.livestrong.com/article/431600-what-minerals-convert-amino-acids-to-dopamine-serotonin/

    L-Tyrosine Deficiency Symptoms + Warning Signs of Low Dopamine
    https://nootriment.com/l-tyrosine-deficiency/
     
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  17. drob31

    drob31 Senior Member

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    Thanks for the detailed write-up. I did use Tyrosine 500 mg in the morning on an empty stomach for a good 2 month period, and it helped dramatically. I did seem to crash myself for about 2 weeks but I think it was because I was using allot of caffeine next to it. I cut out the caffeine and I'm back on tyrosine again at a lower dose. (250 mg), and I may pulse it.

    I also had dramatic improvements a few years ago when I had tyrosine + iodine, but I attribute it to the tyrosine, I think the iodine made me go hypo.

    In any case, there seems to be missing co-factors or signaling issues, but it's clear that dopamine is part of the puzzle.
     
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  18. Chocolove

    Chocolove Tournament of the Phoenix - Rise Again

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  19. andyguitar

    andyguitar Senior Member

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    Well those who are interested in this thread have certainly come up with some usefull info. Well done! I spent several years working for someone with severe ME. On the amino acid front the most effective were the Branched Chain Amino Acids. Used by sports people, among other things they stimulate the release of glycogen from the liver. You need that to fuel your brain. They have other effects which might help ME. If you want to give them a try just follow the instuctions on the pack. But best not to take them within 4 hours of going to bed for the ni
     
  20. drob31

    drob31 Senior Member

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    This actually all ties in with the central fatigue hypothesis, where seratonin levels are too high in the brain while dopamine levels are too low. This is what they noticed in atheletes who exhibited CFS like symptoms.
     
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