I have pretty much all the symptoms of CFS: Poor sleep / cycadian rhythm Extreme fatigue at all points in the day Food sensitivities and crashes Sickness type behavior (gravitating to only low energy activities) Brain fog Irritability, hard time ignoring sounds etc Anhedonia Fluctuating vision clarity Constipation, gas, light amounts of bowel irritation. Anxiety Muscle pain Phenibut (aka bioactive GABA B) gives me full remission and utterly changes my behavior. However I can only take it once a month or so, else the effects will get weaker and the withdrawal gets worse. Effects of phenibut: My mind feels perfectly clear, I notice the thousands of simple things that are pleasurable. Rain outside, the smell of my blanket, etc. .I don't get pleasure from things that don't take energy to do (laying down and reading, browsing the internet. pretty much everything I normally do) I don't act lazy, my body feels smooth and energetic I feel like I can easily focus on stuff, like I can 100% ignore things if they aren't relevent and my mind can expand to fit even simple things that I'm thinking about. It feels like time slows down, I can notice facial expressions, I can think about the recent past / future clearly. I don't feel like I'm at the bottom of a mental trench. This is the strangest thing for me. I could actually get hungry and then eat and then feel energy after eating. That freaked me out, I didn't remember that every happening for me, I guess I forgot. Atm food is just something I use to keep myself from dying. My digestion seems to normalize, and some sort of cellular metabolic process also seems to normalize. I poop once daily. GABA and inflammation studies: http://www.ncbi.nlm.nih.gov/pubmed/25526825 http://www.ncbi.nlm.nih.gov/pubmed/25677654 http://www.ncbi.nlm.nih.gov/pubmed/25848767 GABA can also regulate several hormone systems: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108002/ (lots more stuff on this, I just didn't want to go find them) It is a real shame that I found something that works but it only works once a month. And it doesn't really decrease the scope of what my issue is, because it has such a wide range of interactions. Anyone else try phenibut / baclophen and get a good result? Any comments on possible MoA's or alternatives?