Just a little more information on antibiotic protocols. The MP uses very low dose, pulsed antibiotics, with another drug that ameliorates some of the herxheimer reactions one can get with regular doses of antibiotics and provides some protection from organ damage, it is claimed. And it uses different antibiotics, ones that often are less troublesome. Tetracycline and doxycycline are not used. Different antibiotics work in different ways, but I don't remember the exact details. There is also another protocol called The Roadback. I am not really familiar with it, but I've heard it also uses pulsed antibiotics. I'm not saying you can do either, but others with your problems have been able to do antibiotics this way, so it might be worth another look, and a read of other patients ways of dealing with your same symptoms. You might need to treat your gut and IC problems first, to the extent possible. And anyone taking antibiotics needs to reintroduce the good bacteria needed by the gut, as in yogurt and kefir, on a daily basis. Re: what others are saying about vitamin D. I have noticed that it is the latest 'miracle' supplement to be hyped and boosted by the supplement industry. Many of the studies proclaiming a need for it have been done by the companies that manufacture it, or by researchers paid by those manufacturers. No bias, no spin there! Some of them even state conclusions that are inconsistance with their evidence, since many people, including doctors, only read the conclusions. It is stored in body fat, so tests of D in circulating blood can be misleading as to how much you actuallyhave in your whole body. The supplement sellers periodically hype one product or another as the latest miracle. I remember when it was vitamin E. Had to have it in everything, including hand lotion, although the research had shown that vitamin E in the diet was an antioxidant and good for the skin, but on the skin it had a negative affect when exposed to the sun. I still see it in topical creams and lotions. Remember when vitamin C was the magic bullet for every illness? The argument that these supplements are cheap so why should they be promoted overlooks the "loss-leader" aspect of marketing. The loss-leader is a product that sells at cost or below cost, designed to get the customer in the door, or onto the website, so that other more expensive products can be pitched, or the same product can be sold in 'magic' combinations with other, more expensive supplements. Much of the recent flurry of interest in vitamin D is driven by marketing, not concern for anyone's health. Get your noni berry juice, your chia seeds (this cheap "chia pet" seed was recently being sold for $50/bottle + shipping, in an email ad to me...enough for one month, or 10 chia pets, which ever comes first!), your flaxseeds, your aloe vera juice at $15/quart...include this in your purchase of vitamin D and get....free shipping! Act now, supplies are limited, limited time offer....well, you get the picture. As long as they state their FDA disclaimer in small print on the website, that none of their products "are intended to diagnose, treat or cure any illness or disease", they can then go on and make those very claims, often in roundabout ways. Ad agencies have long known that the more times someone hears, or reads, something the more likely they are to believe its true. So they bombard the internet and the blogs and the health food stores with 'informative' stories and studies, many of them rewritten and simply copied over and over. Likewise the phony testimonials. Even if you can't do antibiotics, you can listen to your body and avoid sun exposure. Use of zinc-containing creams on the exposed parts, like your face and hands, covering up, avoiding going out in the daytime when possible, using the NOIR (no-infrared) sunglasses the MP protocol promotes, using hats, and in my case, an umbrella when I go out in the sun, can also help you avoid overexposure to the sun. There is even a type of clothing fabric that offers more exclusion of the sun's rays...expensive I hear, but to some sufferers, it makes the difference between going to work or staying home. Where to find it kinds of info are also available on the MP site, even if you can't do the antibiotics. Good luck and take care.