I got one response on my previous post, but wanted to see if there are any others.... I am homozygous for MTHFR mutation and am self treating with l-methylfolate 1000 mcgs, as i've heard that folic acid is not good for me sine I cannot metabolize it. At any rate, I was getting over a cold when I first started to take it and then bam, major sore throat. At first, I did not think there was a correlation, but every day I took it since, bad sore throat. I am not going to take it today to see if there are any improvements at all. Just wondering if it's normal, that's all. Thank you very much for your support.