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Anybody else using DIY transdermal B12?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Soporificat, Jul 9, 2015.

  1. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    The liquid does not stain my skin. I need to use enough alcohol and lotion so that it does not 'sweat' back to the surface and stain my clothes.

    I switched from tablets because they were damaging my teeth.
     
  2. Johnmac

    Johnmac Senior Member

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    I tend to think transdermal is the way of the future, given the hassle & dental problems with holding tabs in your mouth for an hour.

    I've used a mix of methylfolate, methyl B12, B2 & B1 - crushed & mixed with oil, then applied to my skin for a few hours under a bandage. (The B2 & B1 were on the recommendation of Greg the Australian B12 oils guy, who says that B2 helps B12 a lot, & B1 helps B2.)

    When I first tried it I was able to reduce my daily folate dose by 1/3 - tho to be entirely fair that may have been because I didn't need the amount of sublingual folate I was taking in the first place.

    I was euphoric for about a week when I switched to TD: I assume this was more B12 > serotonin. Interesting, as the dose hadn't changed. I surmise that because the Country Life 5mg mB12 tab I was taking dissolved in my mouth so quick, I wasn't getting most of the 5mg; and that grinding it up & putting it against my skin made it last much longer, giving me a much slower and therefore larger penetrative dose.

    I've since switched to the Australian oils for B12, but no changes yet.

    My situation is complicated by the recent realisation that I don't know whether my big changes on the Freddd Protocol have been from folate, B12 or both. I can't really tell: I guess the way to do that is reduce doses of one but not the other & see what happens...

     
    Last edited: Feb 27, 2016
  3. drew

    drew

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    @Johnmac

    Why couldn't you just take a b complex pill and the b12 transdermally?
     
  4. maryb

    maryb iherb code TAK122

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    @Johnmac
    Which brand of the Bs did you use TD. I would like to try this way. I have a transdermal multi vit/mineral body spray from my doctor but my skin just sweats it back out and all my clothes get covered in pink stuff.
    @drew - for me any oral b complex makes me feel like I've been poisoned, not sure how it affects others.
     
    Last edited: Feb 28, 2016
  5. John Mac

    John Mac Senior Member

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    Different John Mac @maryb
    The one you want is @Johnmac
     
    maryb likes this.
  6. drew

    drew

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    What is the difference of potency between methods. How much less would one have to use of the transdermal compared to sublingual?
     
  7. Johnmac

    Johnmac Senior Member

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    Sorry, don't understand the question. Maybe re-read my post.
     
  8. drew

    drew

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    @Johnmac

    You wrote: "I've used a mix of methylfolate, methyl B12, B2 & B1 - crushed & mixed with oil, then applied to my skin for a few hours under a bandage. (The B2 & B1 were on the recommendation of Greg the Australian B12 oils guy, who says that B2 helps B12 a lot, & B1 helps B2.)"

    Why couldn't you just consume a b complex pill? Why does the B complex have to applied transdermally?
     
  9. Johnmac

    Johnmac Senior Member

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    Okay. Because methyl & adenosyl B12 (the types that are of use) don't have much efficacy taken orally; have a bit more efficacy taken sublingually; & a lot more taken transdermally. The absorption rates have been surmised to be 1%, 15% & 80% respectively - tho I don't know if that's true.

    I'm assuming that similar dynamics apply to the other Bs, tho that's a guess. If I find that TD works well for all Bs, I'll just crush up a multi B & do the same (TD).
     
  10. drew

    drew

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    I wonder if one could stop taking lithium if they are taking TD B12 since the absorption rate is much more efficient.
     
    Little Bluestem likes this.
  11. maryb

    maryb iherb code TAK122

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    @Johnmac
    You probably missed my question, which brand B1 & 2 do you use?
     
  12. Johnmac

    Johnmac Senior Member

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    Sorry. Because I've been living in Cambodia, I've been buying brands made there. Amazingly enough, they work.

    I haven't got round to buying a brand from iHerb yet, so can't tell you what is good or not from there, sorry.
     
  13. maryb

    maryb iherb code TAK122

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    Okay thanks.
     
  14. Johnmac

    Johnmac Senior Member

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    I just asked Dr Greg Russell-Jones at B12Oils what the relative penetration rates of different forms of B12. He replied:

    * Oral - 0.1-1% per dose.

    * Sublingual - the same, but the sublingual keeps prolonging the dose. Probably less than 5% after a full day of sucking. It seems to have much less efficacy than this though.

    * Nasal spray - don't know, but data suggests it is more like sub-lingual, and that the uptake mechanism is the same. I would have to check this.

    * Injection - by definition 100%, but you lose it very quickly. The half-life is about 30-60 minutes.

    * Transdermal - In small animals about 80%, but like injection the half-life is 30-60 minutes. We have a study going on, but it isn't finished yet.

    The thing is that to restock the brain you only get a tiny bit across into the brain at any one time, so you need high doses (such as with TD and injectable) around all the time, so that you can maximize this.

    The other thing is that if the material is not loaded onto transcobalamin it gets loaded onto haptocorrin, which can look as if you have it working. The majority of people who have been taking high dose oral or sub-linguals have very high serum b12, but they don't show signs of sufficiency. That is because it is not loaded onto transcobalamin. This is also a problem for IM and TD, but the slower release and drainage seems to be better at loading up transcobalamin.

    Thus, people who have been on high dose oral for years, rapidly get better (over a month or so) after the TD, so there is a big difference.

     
    Last edited: Mar 2, 2016
  15. gettinbetter

    gettinbetter Senior Member

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    Is anyone using Greg's B12 oils specifically the hydroxocobalamin?
    If so how do you like it ?
    Thanks very much
     
    Last edited: Nov 28, 2017
  16. Sundancer

    Sundancer Senior Member

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    this is an interesting thread, I'll bookmark it for later.
    I'm now on 2 mg methylcobalamine and getting the dose up gives me yet too much nasty symptoms. But later on...I'll look at the transdermal DIY.

    I saw a new transdermal sold here in Holland, but did not like the ingredients at all.
    first it is cyanocobalamin...Plus they added perfume...

    and shipping from Australia is too expensive ( but happy for those that live there, things should balance out a little)
     
    Mel9 likes this.
  17. gettinbetter

    gettinbetter Senior Member

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    I think I have had adrenal stress with injectable mfolate I had heart pounding and could not sleep it lasted about 24 hours
     
  18. gettinbetter

    gettinbetter Senior Member

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    Hello Soporificat
    How does this work for you? If you use or have used Greg's oil can you compare?
    Thanks
     
  19. Eastman

    Eastman Senior Member

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    @gettinbetter

    Soporificat has not logged in for almost two years.

    Her last post on this thread suggests that she switched method.

     
    gettinbetter likes this.

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