A while ago I got a blood test for herpes simplex 1 & 2, and the test results came back as: HSV-1 IgG: Positive: Index = 4.212 HSV-2 IgG: Negative: Index = 0.581 Does anyone have experience with this, and can comment on the significance of the HSV-1 titer level of 4.212, in the context of CFS? My main question is whether this HSV-1 titer level of 4.212 indicates that this herpes virus might be active enough to contribute to my overall CFS symptoms? This herpes simplex test was taken when my general CFS symptoms were stable. I did not have a cold sore flare up at the time of this test. I have had herpes simplex 1 since childhood (I know this, as I have always had occasional herpes oral cold sores since childhood).