Sorry I am another one seeking help with interpreting my SNP's for methylation and detox. If any one can make any suggestions on any of the results it would be truly appreciated. Huge thanks in advance My results are: Methylation ++ Bhmt 08 Bhmt 02 VDR taq + - MTHFR 03 P39P MTHFR A1298C COMT V158 COMT H62H MAO-A R297R MTR A2756G MTRR A66G MTRR K350A CBS A360A Detox profile ++ SOD2 A16V + - CYP1B1 L432V CYP1B1 R48G CYO2C9*3 A1075C GSTP1 1105V NAT2 I114T NAT2 R197Q NAT k268R I read this on the genetic genie report, 'With a COMT + status, it has been clinically observed by physicians that people may have trouble with methyl donors'. Can anyone explain what this means? Does this mean all methyl supps?