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Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation

Discussion in 'Other Health News and Research' started by heapsreal, Aug 12, 2014.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    http://jem.rupress.org/content/211/2/189.abstract
     
    Last edited: Aug 12, 2014
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  2. minkeygirl

    minkeygirl But I Look So Good.

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    another nasty toxic drug for us to try.
     
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I wonder how long it takes for this anti-inflammatory effect to work. Those with cfs/me who are responders to antivirals usually take months before noticing benefits. I wonder it not only working on lowering viral load but also in this manner of lowering inflammation.

    Since i have finished continuous antivirals, i have done several short courses. Usually i get viral symptoms and weird types of headaches and cognitive problems. I usually give it a few days to see what happens but if things dont improve i then go back on antivirals for 2-4 weeks. What i have noticed is that within 3 days things seem to be back to normal, is this its anti inflammatory effects working?? This also didnt occur when i first started Antivirals several years ago either But only recently. I guess its also a possiblitiy that my viral load is low enough that if i pick up any reactivation early enough that antivirals will work quicker???

    Is this microglial a part of the autoimmune issues in cfs/me????
     
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    But it can lead to other meds that do the same thing but maybe less toxic??
     
  5. lansbergen

    lansbergen Senior Member

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    Lower viral load causes less inflammation?
     
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  6. minkeygirl

    minkeygirl But I Look So Good.

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  7. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    @lansbergen yes, plus i just dont know if the anti inflammatory effects could also be seperate mechanism or not. The speed of improvement makes me think the anti-inflammatry effects may be seperate or atleast occur quicker then reducing viral load??
     
  8. SOC

    SOC Senior Member

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    Nah, same old "nasty toxic drug", not a new one. We know it as Valcyte.
    Interesting question. Both times I've taken Valcyte, I've noticed a HUGE improvement in symptoms at the 6-7 month mark. It's so distinct, I've been wondering what could be happening consistently at 6 months -- not before, and not as much later. Maybe it's the anti-inflammatory effect kicking in.
     
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  9. lansbergen

    lansbergen Senior Member

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    Have you searched for these meds lowering oxidative stress?
     
  10. minkeygirl

    minkeygirl But I Look So Good.

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    I googled it and it called it Cytovene.
     
  11. SOC

    SOC Senior Member

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    Cytovene is the IV form. The oral form is the prodrug Valcyte.
     
  12. minkeygirl

    minkeygirl But I Look So Good.

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    I'm just saying, nowhere does it say Valcyte
     
  13. SOC

    SOC Senior Member

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    http://en.wikipedia.org/wiki/Ganciclovir

    Valganciclovir is Valcyte. Valcyte is the trade name.
     
  14. Daffodil

    Daffodil Senior Member

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    i guess this explains why valcyte helped a tiny bit a few years ago, when i was bedridden. i never really had high antibodies to the herpes viruses.
     
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