My feeling is that antibiotic's play a role in setting up the perfect conditions to contract ME in future years and perhaps other illnesses as well. Wrong doses or incorrect antibiotic for the infection targeted, I believe can change the microbiota of the mucus membranes in localized areas throughout the body ( sinuses, lungs, gut, genital tract, bladder ). Causing inflammation that does not go away. The immune system is then constantly activated. Over years the continual immune activation causes generalized inflammation throughout the body, weakening it so much that major dysregulation occurs and perhaps according to one's genetic makeup the pathway is set for auto immune illnesses. Do you think antibiotic's to treat an infection is the beginning cause that started the ball rolling with your ME ? Did you notice a significant change in your body after a treatment of antibiotic's leaving you with an inflammation ? I would be interested to know if others also think antibiotic's are a culprit in the early set up of this illness before onset ME occurred.