1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Hyperparathyroidism: An Often Overlooked Differential Diagnosis to ME/CFS
Andrew Gladman puts hyperparathyroidism under the microscope, exploring what the disease is, how it can mimic ME/CFS in presentation and how it is treated.
Discuss the article on the Forums.

Antibiotic's - A Blessing and a Curse ?

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by rosie26, Jul 18, 2014.

  1. rosie26

    rosie26 Senior Member

    Messages:
    1,048
    Likes:
    1,318
    NZ
    My feeling is that antibiotic's play a role in setting up the perfect conditions to contract ME in future years and perhaps other illnesses as well.

    Wrong doses or incorrect antibiotic for the infection targeted, I believe can change the microbiota of the mucus membranes in localized areas throughout the body ( sinuses, lungs, gut, genital tract, bladder ). Causing inflammation that does not go away. The immune system is then constantly activated.

    Over years the continual immune activation causes generalized inflammation throughout the body, weakening it so much that major dysregulation occurs and perhaps according to one's genetic makeup the pathway is set for auto immune illnesses.

    Do you think antibiotic's to treat an infection is the beginning cause that started the ball rolling with your ME ? Did you notice a significant change in your body after a treatment of antibiotic's leaving you with an inflammation ?
    I would be interested to know if others also think antibiotic's are a culprit in the early set up of this illness before onset ME occurred.
     
    Last edited: Jul 20, 2014
    aimossy, AbbyDear and Gingergrrl like this.
  2. minkeygirl

    minkeygirl Narcissism = lack of self awareness

    Messages:
    2,282
    Likes:
    1,475
    Left Coast
    In my case no. Mine was a perfect storm of cortef and a virus. I did not take ABX at that time.
     
    maryb and rosie26 like this.
  3. Gingergrrl

    Gingergrrl Community Support Volunteer

    Messages:
    1,868
    Likes:
    3,124
    USA
    @rosie26 Absolutely 100% in my case. I had a severe neurotoxic reaction to the antibiotic Levaquin that both injured the tendon in my arm and caused a systemic toxicity which I was hospitalized for. It took me a year and a half to fully recover including six months of physical therapy for my arm and my body was never the same.

    Unfortunately exactly two years after my Levaquin disaster, I got a severe case of mono from EBV. This was the true cause but the effects were cumulative and it started a cascade that I have not been able to recover from. I wonder if I had not first had the Levaquin reaction, if I would never have gotten mono/EBV or if I would have been able to recover from it without going on to develop ME/CFS.
     
    rosie26 likes this.
  4. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

    Messages:
    2,638
    Likes:
    1,993
    Midwest, USA
    I have been prone to rebound infections after taking antibiotics all of my like. The rebound infection following the 'really nasty flu' was devastating. I sometimes wonder if could have avoided it, I might have avoided the ME.
     
    rosie26 likes this.
  5. Hanna

    Hanna Senior Member

    Messages:
    403
    Likes:
    360
    Jerusalem, Israel
    I do not know for sure. But prior to sudden onset of M.E , I had several courses of Flagyl for amybiasis, first course beeing 01/1997 - onset of M.E 06/1998. Can't speak about causality though.
     
    rosie26 likes this.
  6. rosie26

    rosie26 Senior Member

    Messages:
    1,048
    Likes:
    1,318
    NZ
    Thanks Gingergrrl. Interesting to hear your experience. You must have felt absolutely awful with systemic toxicity.
    I was never the same either after my experience with an antibiotic when I was 20 years old. My health seemed to slowly go downhill from there. I was a very healthy person and no reason to fall sick at a young age. It was a nasty flu that was the last straw for me years later.

    The distance between the cause and then trigger onset into ME varies in us all - I guess depending on many other factors. I really don't think I would have got ME if I hadn't of had that antibiotic episode. Something major happened there that has undone my health.
     
    Gingergrrl likes this.
  7. rosie26

    rosie26 Senior Member

    Messages:
    1,048
    Likes:
    1,318
    NZ
    Me too with rebound infection.
     
    Little Bluestem likes this.
  8. rosie26

    rosie26 Senior Member

    Messages:
    1,048
    Likes:
    1,318
    NZ
    Thanks for your comments Hanna.
     
    Hanna likes this.
  9. Iquitos

    Iquitos Senior Member

    Messages:
    374
    Likes:
    555
    Colorado
    I don't think so, but who knows?

    I do know that when I tried the Marshall protocol, using pulsed antibiotics, it eliminated my back pain, but didn't do a thing for the exhaustion and that's why I quit it. Then I moved to Central America and began taking doxycyline as a prophylaxis against maleria and I found it also lowered my back pain. At times I've stopped the doxy, either because I was out of it, or I wanted to see if it really made any difference, and I've found that back pain and muscle spasms increase when I'm not taking it. But that's just one type of antibiotic and there are several types so this might not apply to all types.
     
    rosie26 likes this.
  10. maryb

    maryb iherb code TAK122

    Messages:
    2,882
    Likes:
    2,012
    UK
    @Iquitos
    I just read on Dr Myhill's page about some research on lower back pain and infections. If you search on 'chronic infection' it should bring up the page. Very interesting given your response to antibiotics and a decrease in pain.
    I am currently in a great deal of pain with my back so it definitely gave me food for thought.
    The antibiotic used was amoxiclav. (Augmentin)

    http://www.ncbi.nlm.nih.gov/pubmed/23404353

    just got the link if anyone interested.
     
    Last edited: Jul 20, 2014
    Iquitos and rosie26 like this.
  11. minkeygirl

    minkeygirl Narcissism = lack of self awareness

    Messages:
    2,282
    Likes:
    1,475
    Left Coast
    @maryb Interesting about the Augmentin since that is the ABX of choice for sinus infections.
     
    rosie26 likes this.
  12. Gingergrrl

    Gingergrrl Community Support Volunteer

    Messages:
    1,868
    Likes:
    3,124
    USA
    @rosie26 I am extremely cautious and fearful of antibiotics after what happened to me with Levaquin but I also know that most antibiotics in other classes (not fluoroquinolones) do not cause that kind of systemic toxicity and tendon damage/ruptures. For me, Levaquin was the moment that my health changed and I truly regret taking it but I know that antibiotics can be life saving so I try to keep an open mind that others have not had my experience (but still try to warn others re: quinolones.)
     
    Hanna and rosie26 like this.
  13. rosie26

    rosie26 Senior Member

    Messages:
    1,048
    Likes:
    1,318
    NZ
    @Iquitos @maryb :) that was interesting about back pain and antibiotic's - ugh I have been getting lower back pain this year. Just have to figure out what is causing it - I do have a disc problem that keeps catching I think. But two other things possibly causing back pain too.
     
  14. Iquitos

    Iquitos Senior Member

    Messages:
    374
    Likes:
    555
    Colorado
    For me, the vagus nerve theory of causation works for me. Thread elsewhere here on PR. The infection can be anything from bacteria to virus to parasite.
     
    rosie26 likes this.
  15. rosie26

    rosie26 Senior Member

    Messages:
    1,048
    Likes:
    1,318
    NZ
    Thanks Iquitos. I am interested in hearing everyone's theories. The more the better as far as I am concerned. I appreciate the time people take to say what they think may be involved. I think the bacteria one is another one for me as well. Bacteria + antibiotic's seems more likely in my case. But ultimately as you say 'who knows'.

    I hope we get to the cause/s one day but I know the researchers have to work backward first.
     
  16. rosie26

    rosie26 Senior Member

    Messages:
    1,048
    Likes:
    1,318
    NZ

    I know what you mean Gingergrrl. Even though I think antibiotic's were part of my beginning cause I still take antibiotic's when I need them :rolleyes: I think we are so fortunate to have antibiotic's and they have saved me a lot of horrid pain many times. I don't know whether I have ever taken quinolones. I will have to find out all the names of them.
     
    Last edited: Jul 22, 2014
    Gingergrrl likes this.
  17. Gingergrrl

    Gingergrrl Community Support Volunteer

    Messages:
    1,868
    Likes:
    3,124
    USA
    @rosie26 The main ones prescribed today in the U.S. are Levaquin, Cipro, Floxin, and Avelox. I would avoid those at all cost but please google so you are not just taking my word for it.
     
    rosie26 likes this.
  18. rosie26

    rosie26 Senior Member

    Messages:
    1,048
    Likes:
    1,318
    NZ
    Bacteria ... antibiotic's ... auto-inflammatory or autoimmune ... flu ... ME. I think that's me. Could be wrong though :rolleyes:
     
    Last edited: Aug 2, 2014

See more popular forum discussions.

Share This Page