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Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and ..

Discussion in 'Lyme Disease and Co-Infections' started by shrewsbury, Mar 28, 2010.

  1. shrewsbury

    shrewsbury member

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    Tate Mitchell posted this to CO-CURE Mar 17 2010

    Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms

    Chandra A, Wormser GP, Klempner MS, Trevino RP, Crow MK, Latov N, Alaedini A.
    Department of Neurology and Neuroscience, Cornell University, New York, NY, USA.
    Brain Behav Immun. 2010 Mar 11. [Epub ahead of print]

    http://www.ncbi.nlm.nih.gov/pubmed/20227484


    Some Lyme disease patients report debilitating chronic symptoms of
    pain, fatigue, and cognitive deficits despite recommended courses of
    antibiotic treatment. The mechanisms responsible for these symptoms,
    collectively referred to as post-Lyme disease syndrome (PLS) or
    chronic Lyme disease, remain unclear. We investigated the presence of
    immune system abnormalities in PLS by assessing the levels of
    antibodies to neural proteins in patients and controls. Serum samples
    from PLS patients, post-Lyme disease healthy individuals, patients
    with systemic lupus erythematosus, and normal healthy individuals were
    analyzed for anti-neural antibodies by immunoblotting and
    immunohistochemistry. Anti-neural antibody reactivity was found to be
    significantly higher in the PLS group than in the post-Lyme healthy
    (p<0.01) and normal healthy (p<0.01) groups.
    The observed heightened
    antibody reactivity in PLS patients could not be attributed solely to
    the presence of cross-reactive anti-borrelia antibodies, as the
    borrelial seronegative patients also exhibited elevated anti-neural
    antibody levels. Immunohistochemical analysis of PLS serum antibody
    activity demonstrated binding to cells in the central and peripheral
    nervous systems. The results provide evidence for the existence of a
    differential immune system response in PLS, offering new clues about
    the etiopathogenesis of the disease that may prove useful in devising
    more effective treatment strategies.


    Copyright 2010. Published by Elsevier Inc.
  2. My ANA was high for years, 15 or more, then it crashed to Zero. They have a function

    Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms

    Chandra A, Wormser GP, Klempner MS, Trevino RP, Crow MK, Latov N, Alaedini A.
    Department of Neurology and Neuroscience, Cornell University, New York, NY, USA.
    Brain Behav Immun. 2010 Mar 11. [Epub ahead of print]

    http://www.ncbi.nlm.nih.gov/pubmed/20227484


    Some Lyme disease patients report debilitating chronic symptoms of
    pain, fatigue, and cognitive deficits despite recommended courses of
    antibiotic treatment. The mechanisms responsible for these symptoms,
    collectively referred to as post-Lyme disease syndrome (PLS) or
    chronic Lyme disease, remain unclear. We investigated the presence of
    immune system abnormalities in PLS by assessing the levels of
    antibodies to neural proteins in patients and controls. Serum samples
    from PLS patients, post-Lyme disease healthy individuals, patients
    with systemic lupus erythematosus, and normal healthy individuals were
    analyzed for anti-neural antibodies by immunoblotting and
    immunohistochemistry. Anti-neural antibody reactivity was found to be
    significantly higher in the PLS group than in the post-Lyme healthy
    (p<0.01) and normal healthy (p<0.01) groups.
    The observed heightened
    antibody reactivity in PLS patients could not be attributed solely to
    the presence of cross-reactive anti-borrelia antibodies, as the
    borrelial seronegative patients also exhibited elevated anti-neural
    antibody levels. Immunohistochemical analysis of PLS serum antibody
    activity demonstrated binding to cells in the central and peripheral
    nervous systems. The results provide evidence for the existence of a
    differential immune system response in PLS, offering new clues about
    the etiopathogenesis of the disease that may prove useful in devising
    more effective treatment strategies.


    Copyright 2010. Published by Elsevier Inc.[/QUOTE]

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