i posted this below info on another thread (found here: http://www.forums.aboutmecfs.org/sh...-replication-of-XMRV&highlight=spironolactone) but given my good results taking this med, i've decided it is time to dedicate a whole thread just to this med. here is what i posted in the earlier mentioned thread: _____ originally posted on july 8, 2010: there is this med that lowers androgens. it is called spironolactone. http://en.wikipedia.org/wiki/Spironolactone i took it for years to lessen my body hair that i get from polycystic ovaries. a few years ago i stopped taking it on a whim. and then i got much sicker. i did not put one and one together until i heard judy mikovits say in november 2009 that cortisol, estrogen and androgens make xmrv reproduce. so last month i asked judy if, in theory, spironolactone would help lessen xmrv due to its anti-androgen effects. she said yes, in theory, and she wants to test it in the lab. (i doubt she has, given all the politics happening. but i'll ask her again.) so i went back on spironolactone a few weeks ago, at a tiny dose, and started to do somewhat better. and my brain started working better too. less brain fog. then just 6 days ago i doubled the dose and within 2 days felt a lot better. a lot. so it is only 4 days of doing better. but it is curious how linked it is to the spironolactone. does anyone want to experiment with this and get a prescription of spironolactone and try it yrself? i'd love to hear if anyone else gets help from this med. it is easy to take. no side effects in me (over the years) except a bit more liquidy period, less clotty (eeeeeeewww! too much information!!!!!) i'll now repost some earlier posted info, as it relates: Androgen Stimulates Transcription and Replication of Xenotropic Murine Leukemia Virus-Related Virus Beihua Dong and Robert H. Silverman* Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195 Received 20 August 2009/Accepted 4 November 2009 Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus originally identified in a subset of prostate cancer patients. Because androgens stimulate prostate tumors and some retroviruses, we investigated the effects of dihydrotestosterone (DHT) on XMRV transcription and replication. Transcription from the XMRV U3 region was stimulated up to 2-fold by DHT, but only in cells containing a functional androgen receptor. Mutations in the glucocorticoid response element (GRE) of XMRV impaired basal transcription and androgen responsiveness. Furthermore, DHT stimulated XMRV replication 3-fold, whereas androgen inhibitors (casodex and flutamide) suppressed viral growth up to 3-fold. Findings suggest that integration of the XMRV long terminal repeat (LTR) into host DNA could impart androgen stimulation on cellular genes.