Julie Rehmeyer's 'Through the Shadowlands'
Writer Never Give Up talks about Julie Rehmeyer's new book "Through the Shadowlands: A Science Writer's Odyssey into an Illness Science Doesn't Understand" and shares an interview with Julie ...
Discuss the article on the Forums.

ANP, the link between low blood volume and Сhronic Fatigue Syndrome?

Discussion in 'General ME/CFS News' started by Emootje, Jun 27, 2010.

  1. Emootje

    Emootje Senior Member

    Messages:
    345
    Likes:
    231
    The Netherlands
  2. Merry

    Merry Senior Member

    Messages:
    1,358
    Likes:
    622
    Columbus, Ohio, USA
    Wow! Thank you, Emootje.

    Merry
     
  3. Tammie

    Tammie Senior Member

    Messages:
    761
    Likes:
    20
    Woodridge, IL
    very interesting.....would it be possible for you to put the first couple of minutes (the explanation part) on here in writing?
     
  4. Emootje

    Emootje Senior Member

    Messages:
    345
    Likes:
    231
    The Netherlands
    It is possible:
    Atrial natriuretic peptide is a natural diuretic that is produced in the atrium of the heart.
    For example:
    When you eat soup, your blood volume expanse and your heart is getting larger. This causes the atrial walls to stretch.
    It then releases atrial natriuretic peptide, whit’s travels to the bloodstream to the kidney, wit’s then causes the kidney to produce more urine, that will normalize your blood volume and your atrial natriuretic peptide levels again.

    In some disease the body is fooled to think there is too much fluid in the body.
    These disease are almost all characterized by an increase in endothelin-1, a vasoconstrictor and a potent atrial natriuretic peptide stimulator.
    This activation of the endothelin-1/atrial natriuretic peptide pathway results in chronic low blood volume.
    The endothelin-1/atrial natriuretic peptide pathway is stimulated by:
    Oxidative stress such as isoprostanes and oxidized low-density lipoproteins
    Inflammation factors such as interleukin-1, interleukin-3, tumor necrosis factor alpha, interferon gamma, transforming growth factor beta and endotoxin.
    Hypoxia

    Some examples of diseases with increased endotelin-1/atrial natriuretic peptide pathway activation and hypovolemia are: biliary obstruction, sleep apnea, chronic obstructive pulmonary disease with hypoxia and septic shock.

    Chronic fatigue syndrome is characterized by low blood volume, cytokines abnormalities, oxidative stress and a low peak oxygen consumption. This low blood volume could be explained by high atrial natriuretic peptide levels stimulated by inflammation, hypoxia or oxidative stress.

    Emootje
     
    merylg, MeSci, cigana and 1 other person like this.
  5. Sallysblooms

    Sallysblooms P.O.T.S. now SO MUCH BETTER!

    Messages:
    1,767
    Likes:
    346
    Southern USA
    Thank you for the information!
     
  6. MaryAnn

    MaryAnn

    Messages:
    44
    Likes:
    0
    Thank you - this is very informative
     
  7. ixchelkali

    ixchelkali Senior Member

    Messages:
    1,105
    Likes:
    274
    Long Beach, CA
    Thanks, very interesting. Is there a test for endothelin-1 levels, do you know?
     
  8. Emootje

    Emootje Senior Member

    Messages:
    345
    Likes:
    231
    The Netherlands
  9. Tammie

    Tammie Senior Member

    Messages:
    761
    Likes:
    20
    Woodridge, IL
    Thank you!! : )
     
  10. aaron_c

    aaron_c Senior Member

    Messages:
    601
    Likes:
    868
    @Emootje: It has been a while since this all was posted. Do you still think endothelin-1 levels are raised in CFS/ME?
     
  11. Emootje

    Emootje Senior Member

    Messages:
    345
    Likes:
    231
    The Netherlands
  12. lauluce

    lauluce as long as you manage to stay alive, there's hope

    Messages:
    357
    Likes:
    574
    argentina
    thanks for the info!
     
  13. out2lunch

    out2lunch Senior Member

    Messages:
    194
    Likes:
    295
    Interesting about what increases ANP. I watched your "Factors that increase ANP" video, and I'm a bit confused about how specifically these factors affect ANP. For instance, vasopressin. Is it elevated ADH that affects ANP increase? Or is it decreased ADH that affects it?

    I've been tested for everything on your list in the video except endothelin-1 and isoprostanes. Everything is in the normal range except for vasopressin/ADH, which is always almost non-existent, and transforming growth factor beta, specifically TGF-B1, which is always at least five times higher than the upper normal range limit, like most of Shoemaker's patients.

    Since ANP inhibits renin secretion, this would easily explain why my renin values are always below normal when measured. My aldosterone and angiotensin II are in the normal range, but not renin. And having elevated ANP would readily explain this.
     
  14. MeSci

    MeSci ME/CFS since 1995; activity level 6?

    Messages:
    7,840
    Likes:
    12,237
    Cornwall, UK
    I note that
    Maybe this means that they were relatively well-rested. Perhaps levels would be different after exertion?
    This page says that ET-1
    The aldosterone would be anti-natriuretic and anti-diuretic. So ET-1 regulates these according to conditions?
     
  15. Emootje

    Emootje Senior Member

    Messages:
    345
    Likes:
    231
    The Netherlands
    @MeSci: I guess that ANP protects the heart (at the expense of blood volume) from to much pressure from potent vasoconstrictors like ET-1.

    @out2lunch: Vasopressin increases ET-1 (table 1) so I guess that elevated ADH will stimulate ANP secretion.

    et-1.png

    On the other hand, in this review they mentioned that ANP inhibit vasopressin release.
    Interesting about your low renin values, POTS patients have also low renin values and in this study they noted that ANP or dopamine could be the cause of this low renin. Normally if renin is low, the downstream hormones (angiotensin II and aldosterone) are also low, so that is a little bit weird that your aldosterone and angiotensin II are in the normal range. Lastly, transforming growth factor beta can activate MAPK p38 and vise versa. Inhibiting MAPK p38 could theoretical be helpful to lower ANP.
     
    merylg likes this.

See more popular forum discussions.

Share This Page