Hi all, I'm looking for some help just making basic sense of my SNP's. I've been reading up on MTHFR for a while on the suspicion that I was positive. But with the rest of my info, everything I read seems to conflict and I am just bewildered. So, here are my SNP's, per GG: MTHFR, all heterozygous MTHFR C677T MTHFR 03 P39P MTHFR A1298C Homozygous Mutations: VDR Taq MTRR A66G Heterozygous Mutations: COMT V158M COMT H62H MAO-A R297R ACAT1-02 MTRR A664A CBS A360 As for me, my issues are: autoimmune achalaisa, an esophageal disorder that is largely under control now with dietary modification; IBS; constant fatigue, insomnia, and irritability/anger. I also have a dx of major and low grade depression and anxiety, though I haven't been medicated for a long time. I have been on a variety of Paleo-style diets since June of 2012, doing GAPS and AIP with some improvement, though I didn't have serious insomnia issues prior to Paleo. I've definitely got serious motivation issues and follow through issues that I didn't used to have before a major depressive bout in 2007. I've been working hard to heal my gut, but apart from managing my esophageal spasms and helping me lose about 60 lbs, I still have IBS symptoms and gain a lot of weight if I even look at grains. I have yet to find a supplement that helps me feel good for more than a day or two - Thorne MethylGuard + does nothing for me, nor do tons of ferments, nor zinc, nor turmeric, 5-htp or melatonin. Digestive enzymes are about the only thing I am religious about. I know that I don't do well on very low carb, it totally messes up my hormones, and makes my armpits smell like ammonia, so I do try to eat a wide variety of veggie carbs. Unfortunately, I don't have the money to run a lot of expensive testing at this point, so I'm just trying to figure things out on my own. I'm a big fan of dietary modification. If anyone can tell me where I need to at least start, that would be fantastic. ETA: I also have major low sex drive so I'm sure there is another hormonal or neurotransmitter issue there.