The drug Rituximab is among other things used against rheumatoid arthritis. The rheumatoid arthritis drug Anakinra has been suggested against ME, although I haven't found it mentioned by any patients on these forums. My last symptom flare, which I am struggling with now, was accompanied with moderate to strong rheumatic like pain in the joints on both hands. That, and a lot of other symptoms like more brain fog, more vision problems, more of most things, flared up. So, I am thinking perhaps it would help. Have anyone here direct experiences with anakinra (kineret) yourselves?