Yes I have. How do you think I got into all of this years ago. And before I started I had Rich Vank look at my lab data via private communications. And it has taken me over 2 years to converge on something that seems to work for me. My confusion is why your response to the following statement: "I strongly disagree with the assertion that methylation supplements will NOT affect a healthy person. BS. Maybe small amounts like in Rich Vanks protocol but even then I am not sure." Note the bolded "NOT". Hence I assert that even perfectly healthy people WILL have some reaction to methylation supplements and too many will overload even them. My only caveat is that maybe smaller amounts like in the SMP will NOT affect a healthy person (say like my wife) much. Methylation affects EVERYONE to some extent. It is basic biochemistry. Sorry. That being said I don't really disagree with what you quoted from Rich. Hb12 did not work for me and I found benefit with adb12 and I take 800 mcg of 5mthf per day. On another note Lotus what protocol are you using now?