Mercury and arsenic inhibit the citric acid cycle. https://www.ncbi.nlm.nih.gov/books/NBK22340/ In general, mercury and other toxic metals disrupt pathways and enzymes all over the body, such as seen in the large metabolomics cycle diagram in the video. Some of these metals are, unfortunately, ubiquitous in our environment and bioaccumulate in the body, starting in utero, from the mother. The half life of their natural detoxification can be decades, therefore, you need to chelate them out to get a timely resolution. If this ends up being "the" root cause, and Ron can come up with a better way to chelate or a workaround for these metals, that would be huge, not only for ME/CFS, but also 30 other major diseases.