The Power and Pitfalls of Omics: George Davey Smith’s storming talk at ME/CFS conference
Read about the talk that stole the show at a recent ME/CFS conference in Simon McGrath's two-part blog.
Discuss the article on the Forums.

An Update on ME/CFS Research with Ronald W. Davis, PhD

Discussion in 'Latest ME/CFS Research' started by Ben Howell, Feb 21, 2017.

  1. PatJ

    PatJ far and free I gaze

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    Thank you. I appreciate you taking the effort to transcribe it so quickly.
     
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  2. halcyon

    halcyon Senior Member

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    Is it safe to assume at this point that they have ran serum/cells from other immune mediated diseases that feature fatigue as a symptom through the impedance assay and they look different than ME patients?
     
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  3. Cheesus

    Cheesus Senior Member

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    They didn't mention that, though the impedance assay was specific to metabolic dysfunction rather than immune dysfunction. So I would think it is more important to compare it to metabolic mediated diseases rather than immune mediated diseases.
     
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  4. simeyss

    simeyss NOT MY BOARD

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    Great work, @Cheesus! Is it okay to share this?
     
  5. halcyon

    halcyon Senior Member

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    They're not mutually exclusive. Diseases like MS have metabolic dysfunction as well.
     
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  6. aaron_c

    aaron_c Senior Member

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    Are you able to send the question in for Ron's next Q&A? I'd like to hear the answer too.
     
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  7. boohealth

    boohealth Senior Member

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    Thanks for the transcript--totally mesmerizing how he is using these new technologies.
     
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  8. Lily Valley

    Lily Valley

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    Thank you so much!
     
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  9. lansbergen

    lansbergen Senior Member

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    Yep
     
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  10. Belbyr

    Belbyr

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    Passing this on to my Fb groups and autonomic discussion groups. Exciting!
     
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  11. Forbin

    Forbin Senior Member

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    For example, I'm sure there were many "good" hypotheses about why the moon was covered with dark areas, or "seas"... right up until October 7, 1959 - when Luna 3 discovered that... it wasn't.

    [​IMG]

    ---------------------- Near Side ------------------------------------------------ Far Side -----------------------

    [​IMG]
     
    Last edited: Feb 21, 2017
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  12. Diwi9

    Diwi9 Senior Member

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    Donation made!
     
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  13. adreno

    adreno PR activist

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    Regarding the question about ATP and pyruvate, I believe the problem is that these are not sufficiently bioavailable orally, so supplementing them will have very little effect.
     
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  14. halcyon

    halcyon Senior Member

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    I think they just have other bad effects if applied extracellularly, eg ATP is a danger signal if present in large enough quantities.
     
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  15. Cheesus

    Cheesus Senior Member

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    Yes, of course! I am about to update it with pictures and a few missed words that have been pointed out to me, so if you check it shortly you should see a shinier version.

    EDIT: The document has now been updated.
     
    Last edited: Feb 22, 2017
  16. aaron_c

    aaron_c Senior Member

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    I get energy and then insomnia from too much ATP. I always thought this was because ATP was doing just what I thought it should ie helping my body produce energy, and that, like so many supplements that help with making energy, taking pharmacological doses overwhelmed my body's ability to regulate energy production.

    So Dr. Davis' statement on this made me somewhat concerned, because it made me think that the assay, while able to determine whether a cell is producing a decent amount of energy, might not be able to determine whether that pace is ultimately sustainable. Or maybe it just needs more time to do that, I don't know.

    But Dr. Davis obviously seems to think this will work as a test, so I probably misunderstood something. Can anyone point out what I'm missing?
     
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  17. Cinders66

    Cinders66 Senior Member

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    Thanks Janet.
    Does this mean if the blood cells are removed that the issue in the serum is not immune driven? Sorry my understanding of biology is poor
     
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  18. TreePerson

    TreePerson Senior Member

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    I had this thought too. A burst of adrenaline makes my body work for a short period but makes me very ill later. And I wondered how he would be able to test or protect against this sort of thing.
     
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  19. AndyPR

    AndyPR RIP PR :'(

    Quick reminder, any questions regarding this video that you want to ask of the OMF team please send them to MECFSResearchQuestions@gmail.com, as requested up thread.
     
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  20. ash0787

    ash0787 Senior Member

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    I would rather try injecting pyruvate than eating ATP or bathing in it, as far as I know it has no other usage in the body than an intermediate energy molecule
     

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