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Ampligen On the Clock: Hemispherx's 'Complete Response' Means Ball is Now in FDA's Court Now

Discussion in 'Phoenix Rising Articles' started by Phoenix Rising Team, Aug 2, 2012.

  1. grosolo

    grosolo

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    I don't think Ampligen is the answer. It's not if you believe that ME/CFS has an autoimmune component or that it causes neuroinflammation (and ME definitely does cause neuroinflammation). If you look up the drug under its brand name, none of this info will come to light, but if you go to pubmed and look it up under its chemical name (Poly I:C, or poly-inosinic polycytidilic acid), you'll find lots of hugely discouraging studies, some of which even call Ampligen "neurotoxic."
    I'm not saying this to be discouraging. I want Ampligen to work as much as anyone -- I suffer. But I think there's a reason Ampligen wasn't rushed into duty two decades ago and I think the ME/CFS community might be better served going in other pharmaceutical directions.

    http://www.ncbi.nlm.nih.gov/pubmed/18590811

    http://www.ncbi.nlm.nih.gov/pubmed/21123556

    http://www.ncbi.nlm.nih.gov/pubmed/21296697
    http://www.ncbi.nlm.nih.gov/pubmed/21815968
  2. Doogle

    Doogle Senior Member

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    Reply to grosolo,

    Sorry grosolo, but your information is missing a vital component. Ampligen is not simply Poly I:C as described in the links you presented. Ampligen is a specifically modified form of Poly I:C that retains TLR3 activity but is designed to have a much shorter half-life in the body.
    http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/PTO/srchnum.htm&r=1&f=G&l=50&s1=4,024,222.PN.&OS=PN/4,024,222&RS=PN/4,024,222

    This results in much less toxicity than Poly I:C. The toxicity of Poly I:C was known years before Ampligen because it was researched as an immune stimulant to fight cancer. It proved too toxic for even that use, and Ampligen was invented as a less toxic immune stimulant. Ampligen proved to be very efficacious in stimulating the TLR3 interferon system to fight viruses and also has some anticancer activity.
    SOC and vli like this.
  3. Snow Leopard

    Snow Leopard Senior Member

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    Skepticism about whether doctors or insurance companies will prescribe the drug is a bit premature at this point, the first step is getting the drug approved in the first place.

    Getting a drug approved for CFS or ME sets a major precedent and will benefit us even if we don't ever take it personally.
    alex3619 likes this.
  4. Hip

    Hip Senior Member

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    The apparent autoimmunity and neuroinflammation in ME/CFS are likely caused by one or more infections. Enteroviruses, for example, which are strongly linked to ME/CFS, are inducers of autoimmunity. 1 In general, infections precipitate the production of lots of autoantibodies.

    So by wiping out viral infections with Ampligen, or with some other antiviral developed in the future, you will likely halt the autoimmunity.
  5. Cort

    Cort Phoenix Rising Founder

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    Raleigh, NC
    I don't think Ampligen is 'the answer'; I think it's like part of an answer; pushing forward to a bigger answer...Its definitely a big help....a big big help for some people...a smaller help for others and it doesn't work for others but that's what you'd expect from anything that works in this disorder - until subsets are teased out.
    ggingues and heapsreal like this.
  6. grosolo

    grosolo

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    If the medicine in question causes brain toxicity -- even while stimulating the immune system -- it's still a very flawed treatment. Look up Poly inosinic poly cytidilic acid on pubmed. Scientists now administer Ampligen to mice in order to test other medicines under the conditions of neurotoxicity. IE -- they're using Ampligen to ruin the brains of mice in order to see how other drugs can fix the brain. That says a lot...And these are the non-Hemispherx researchers -- the ones who have no stake in this...

    I don't mean to be a kill-joy. I want everyone to be able to benefit from whatever they can. But there has been so much research that has been glossed over. The whole brand name Ampligen, not to mention the recently made-up fake generic name rintatolimod -- which no one uses -- are modes of obfuscation. Because if you look up the drug under that name, you get very little information. But if you look up studies under its chemical name of poly inosinic poly cytidilic acid, you get so much more...and a lot of it is ugly and scary.
  7. grosolo

    grosolo

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    This patent form just says that polyriboinosinate and polycytidilate were modified to YIELD Poly IC.
    So they didn't modify Poly IC to create a less toxic form. They modified other drugs to create Poly IC. So anytime you see a study coming out now that uses Poly IC, it's using Ampligen, plain and simple...

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