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Amitriptyline and fluoxetine (prozac) treatment

Discussion in 'General Treatment' started by cosmo, May 22, 2013.

  1. cosmo

    cosmo

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    Thank you.

    The thing is, I feel and think I have something else, like an auto immune disorder. I feel like things such as sjogens meet my criteria for everything but when I ask the dr's about it being something else they seem to roll their eyes and dismiss me. I have a positive ANA but it is dismissed as it is a low positive.

    I am a bit lost, but I really do not want to heavily medicate.
  2. svetoslav80

    svetoslav80 Senior Member

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    Some people have reported that antidepressants helped them with depression and ADHD, but I've never heard someone say antidepressants have helped with fatigue. My personal experience is that they made my fatigue worse. For the protocol, I suffer multiple fatiguing disorders, but not CFS.
  3. snowathlete

    snowathlete

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    I have a minor bladder problem which although worse in recent years started before I began amitriptyline - I also meet ME def. either way for me it was worth it because I wasn't sleeping at all before. But there are other thing you can try for sure, probably a good idea but I wouldn't rule it out entirely if you don't get relief elsewhere. For me it improved quality of life from desperately unbearable to bearable.
    taniaaust1 likes this.
  4. Lotus97

    Lotus97 Senior Member

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    cosmo
    Are both medications for depression or is amitryptiline for sleep? Because if you're treating depression then you should only try one medication at a time and start on a low dose. Prozac should be started at 10 mg and amitriptyline (for sleep) should be no higher than 25 mg starting out. If your doc is only prescribing them for depression then I agree with ukxmrv. There's no reason someone should be started with two different antidepressants at once. A second one can be added later on for various reasons, but not at the outset. If the first one works, why take a second one? And it's also important to know which one is causing side effects.
  5. cosmo

    cosmo

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    Both are for cfs as a whole. Apparently it is the standard practise for treatment according to the dr.

    I am to start on the amitryiptiline first and increase it every other day.

    Then when I have reached my limit I take the prozac in the mornings as a pick me up from the ami.
  6. taniaaust1

    taniaaust1 Senior Member

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    I dont know what is making you think that you couldnt have ME (not meeting all the needed criteria??), but if you look on page 3 of the canadian consensus doc... you will see that sjogens is listed as a co-morbid entity to this. Many get Sjogens due to it.

    ME is likely to be an autoimmune issue to and hence other autoimmune issues are more common with it too eg Hashimoto's thyroiditis is also listed as a co-morbid entity to it as well.

    Best luck in working out where you fit with things but dont rule ME as out if you can tick all the boxes.
  7. taniaaust1

    taniaaust1 Senior Member

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    My CFS specialist started me out with only 10mg for amitrypiline for sleep and I was told to raise it after a week (each week raise, if it wasnt working for my sleep seeing it was being taken for sleep and not depression, it's sleep affects were meant to be seen in that week), till I was taking 50mg which was the maximum does he uses for "sleep "issues in his CFS patients. If it didnt work by that point he considered the drug had failed for this. (I developed the bowel issues with it at about 30mg after the 2-3 week but didnt connect the drug to my much worst bowel issues at first, I didnt connect things till I'd actually finished the trial).

    cosmos I assume your doctor is going to have you stop taking it if it doesnt work for sleep? and only have you on the one drug? (Im not knocking your doctor but it seems weird to me to have you on two drugs if the amitrip dont work.. for most of us it dont.. it scored extremely low on a CFS patient survey)
  8. Lotus97

    Lotus97 Senior Member

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    I haven't noticed any side effects from amitriptyline. I've been taking it for 3 years.
  9. taniaaust1

    taniaaust1 Senior Member

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    Those who get the big issues seem to get them early on. I havent heard of anyone yet say they developed issues after being on it for a while.
  10. Lotus97

    Lotus97 Senior Member

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  11. EtherSpin

    EtherSpin

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    this thread has spooked me a tad! I had a very intense, out of nowhere onset of non situational depression,knots in the stomach, constant sinking feeling like standing over an abyss, bit like the feeling for the first 20 seconds after someone informs you a relative died but remaining all day! as I have two young daughters I dont want to see me laid up and in despair I got to my CFS Doc ASAP and got put on 1 prozac daily due to cost (can't afford buproprion AKA Wellbutrin yet, need income protection insurance claim to come through!) . on the one hand, I doubt it would still be in circulation after so long if it wasn't a godsend for some people but man, very easy to find threads online full of people with issues with it triggering suicidal thoughts, anxiety attacks etc!
    on the other hand I feel a reprieve from the worst symptom due to having moved forward a step and spoken to a professional. if anyone has had success with prozac be sure to chime in! (just for depression i mean, not the CFS)
    heapsreal likes this.
  12. adreno

    adreno 3% neanderthal

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    Yeah, I'm doing well with prozac. Don't listen to all the scare mongering. There are far worse drugs than SSRIs. I take only half the regular dose though, so I probably avoid some side effects this way. The trick is to start low and not go higher than needed. Usually SSRIs are overdosed IMO.
    heapsreal likes this.
  13. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Its an individual thing as well as trial and error. I used prozac once at a low dose and it increased my appetite way too much for me. In the past i have found low doses of zoloft ok and also lexapro but they all tend to make me abit sluggish but if i feel i need them i would go back on them. Currently finding 5htp is helping.
  14. EtherSpin

    EtherSpin

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    ah! mine is in capsules and I just take one a day so not sure how to halve but Ill see how I go anyway

    Heapsreal, I didnt know there was danger of appetite increase, Im doing intermittent fasting to Ill try to stay on that as its virtually habit now. ill let the comfort of habit dictate and see how it goes
  15. Goodness to M.E.

    Goodness to M.E.

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    Review: Book by Robert Whitaker; New York, Crown Publishers, 2010, 416 pp.

    Robert Whitaker, a former Boston Globe reporter, was curious about why there has been such a large increase of disabling mental illness in the United States. His book, Anatomy of an Epidemic: Magic Bullets, Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America (Crown Publishers, 2010), begins with these data points: in 1987, the U.S. mental illness disability rate was 1 in every 184 Americans, but by 2007 the mental illness disability rate had more than doubled to 1 in every 76 Americans.

    During this same time period, there has also been a huge increase in psychiatric drug use. Prior to 1988 when Prozac hit the market, the annual U.S. gross for antidepressant and antipsychotic drugs was less than $1 billion, but today those two classes of psychiatric drugs alone gross more than $25 billion a year in the United States. The question for Whitaker was: is it just a coincidence that disabling mental illness and psychiatric drug use have been rapidly increasing at the same time?

    Whitaker does not discount cultural factors that may have something to do with this dramatic increase in mental illness disability. However, he discovered that the most scientifically identifiable factor for the increase of severe psychiatric problems is the increase in psychiatric drug use. He identified a frightening trend: long-term psychiatric drug use has caused children and adults with minor emotional problems to have severe and chronic disorders that result in mental illness disabilities.

    How Psychiatric Drugs Create Chronic Illness

    Whitaker examined the scientific literature over the last 50 years with respect to 2 related questions. First, do psychiatric medications alter the long-term course of mental disorders for better or for worse? Specifically, do they increase the likelihood that a person will be able to function well over the long-term or do they increase the likelihood that a person will end up on disability? Second, how often do patients with a mild disorder have a bad reaction to an initial psychiatric drug that can lead to long-term disability? For example, how frequently does a person with a mild bout of depression become manic in reaction to an antidepressant and is then diagnosed with bipolar disorder?

    He discovered that while psychiatric medications can, for some people, be effective over the short term, these drugs, in long-term use, increase the likelihood that a person will become chronically ill, increasing the possibility that a mild psychological problem will worsen into a debilitating illness. This is especially clear and tragic in the case of children.

    Not too long ago, "juvenile bipolar disorder" was very rarely diagnosed, yet today it is increasingly common. Whitaker points out, "When you research the rise of juvenile bipolar illness in this country, you see that it appears in lockstep with the prescribing of stimulants for ADHD and antidepressants for depression.... Once psychiatrists started putting 'hyperactive' children on Ritalin, they started to see prepubertal children with manic symptoms." Increasing numbers of children have also been prescribed antidepressants, such as Prozac, and a significant percentage of these young people have become manic in reaction to their antidepressants.

    These frightening manic reactions result in heavy-duty antipsychotic drugs as well as "drug cocktails" made up of multiple psychiatric drugs. Whitaker discovered that a high percentage of these medicated kids end up as "rapid cyclers," which means they have severe bipolar symptoms that put them on a path to be chronically ill throughout their lives. Also, antipsychotics such as Zyprexa cause a host of physical problems, including diabetes. Whitaker concludes, "When you add up all this information, you end up documenting a story of how the lives of hundreds of thousands of children in the United States have been destroyed in this way."

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