This strikes me as having potential to not only improve symptoms but also the disease process at a core level, because the negative effects of dopamine on retroviral replication are mediated primarily by the D2 receptor. See the following posts: Aripiprazole reduces HIV viral load likely via D2 antagonism w/ supporting references More warning regarding dopaminergic drugs and retroviral infection Pure speculation: it may even be possible to safely use some of those contraindicated dopaminergic drugs to improve quality of life if you have some adjunctive D2 antagonism on board to mitigate the negative effects. The following thread contains a fairly comprehensive collection of amisulpride studies at the proposed 50mg dose: Amisulpride Update: still wiping out social phobia. From what I can tell, the only significant side effects at this dose seem to be hyperprolactin'ish endocrine stuff in women. Not clear why it doesn't cause as much trouble for men, I'll have to do more research.