I have been taking very low doses (12.5 to 25 mg daily) of the drug amisulpride for around a year now, and I have found this drug quite helpful for a number of mental and cognitive symptoms that arise in ME/CFS and its comorbid conditions. I am writing up my experiences, as I think this drug may benefit other people suffering a similar range of symptoms. At very low doses, amisulpride acts as an antidepressant, anti-anhedonia and anti-anxiety drug. I have found that very low dose amisulpride also helps with attention deficit-hyperactivity disorder (ADHD), reduces noise sensitivity, which is useful, improves sociability, reduces irritability, and treats anxiety psychosis symptoms (anxiety psychosis can arise if you have extreme anxiety disorder). I have all the above conditions, and so I found amisulpride particularly useful. This small scale study of the benefits of amisulpride for ME/CFS found that 25 mg of this drug taken twice daily reduced fatigue and somatic complaints. Amisulpride is not licensed in the US, but it can be obtained from the usual overseas suppliers. I believe the smallest available size of amisulpride tablets is 50 mg, so you will need to cut these 50 mg tablets in half or in quarters if you want to take the very lowest doses of 25 mg and 12.5 mg.