I have been taking very low doses (12.5 to 25 mg daily) of the drug amisulpride for around a year now, and I have found this drug quite helpful for a number of mental and cognitive symptoms that arise in ME/CFS and its comorbid conditions like depression and anxiety disorder. At very low doses, amisulpride is know to act as an: Antidepressant treatment Anti-anhedonia treatment Anti-anxiety treatment I have also found that very low dose amisulpride also: Reduces ME/CFS noise sensitivity symptoms Greatly reduces ME/CFS irritability symptoms Improves sociability Treats anxiety psychosis symptoms (anxiety psychosis from anxiety disorder) Improves attention deficit-hyperactivity disorder (ADHD) I have all the above conditions, and so I found amisulpride particularly useful. This small scale study of the benefits of amisulpride for ME/CFS found that 25 mg of this drug taken twice daily reduced fatigue and somatic complaints. Amisulpride is not licensed in the US, but it can be obtained from the usual overseas suppliers. I believe the smallest available size of amisulpride tablets is 50 mg, so you will need to cut these 50 mg tablets in half or in quarters if you want to take the very lowest doses of 25 mg and 12.5 mg. BUYING AMISULPRIDE: Amisulpride can be bought prescription-free from any of the following pharmacies: 1 , 2 , 3 , 4 , 5 , 6 .