I think 3 amino acids somehow got my detox pathways working as they should. For years I reacted very strongly to any substance which had "cleansing" or "detox" properties - e.g., apple cider vinegar, chlorella, cayenne - there were several others which don’t come to mind right now. Often something would seem to hit me out of the blue and I’d have to look at everything I was eating or taking to nail down the culprit (which I usually found). A detox foot bath wiped me out badly for 3 days, as did 20 minutes in a FIR sauna. A large part of the time I seemed to detoxing, and I believe it was primarily from mercury. I had spaciness, difficulty concentrating (felt like I was stoned - yes, familiar from many years ago! fatigue, and digestion screwed up. I had around 10 fillings removed in around 1997. I felt no different afterwards. I tried Andy Cutler’s protocol a few years ago, stuck it out for 3 or 4 months, felt no different, and was extremely discouraged to read it could take years. About 2 years ago I started taking gelatin at night for sleep because of its high glycine content. The first night I took it I felt like I’d been hit by a truck, and got lost the next day two blocks from my sister’s house - I could not figure out how to get there, I had to call her to get me there - obviously a major detox reaction. I somehow managed to keep taking gelatin, probably cut the dose and now I’m able to take pure glycine (which was way too strong for me before) 3 grams at night for sleep with no problem. I had a similar experience with inositol, though not as extreme, but again, I’m now taking it with no problem at night for sleep. Glutamine did the same thing, caused detoxing, again though not as extreme as the glycine. I started taking BCAAs and glutamine last November for PEM. And I discovered pretty quickly that one of the properties of glutamine is, you guessed it - detoxing! I stuck with it by lowering the dose. I’m now taking all three of these amino acids with no problem, and I have not had any detox symptoms for five or six months. Glycine, inositol and glutamine are all mentioned as being important for phase II liver detoxification in this article: http://www.diagnose-me.com/treatment/liver-detoxification-phase-II-support.html I also take taurine, choline and cysteine which are also mentioned in the article, although I never noticed any detox symptoms when I took them as I did with the other 3 amino acids. My guess is that these amino acids helped get my detox pathways working how they should. Of course a good test would be to try a FIR sauna again, which I probably will do some time just to see what happens. In February of this year, right around when my detoxing seemed to stop, I had the Quicksilver mercury tri test done (https://www.quicksilverscientific.com/mercury-testing/testing/mercury-tri-test), which showed that my mercury levels were very low and that my detox capabilities were just fine. Well, they weren’t fine for years and years prior to then. I’ve forgotten how bad it used to be and just how often I would be detoxing. Last year when I increased my folate by 800 mcg. I was truly impaired for almost a week until I figured out what was going on and in the meanwhile bought a cell phone I didn’t really want or need. I felt like I was on a drug. The amino acid doses I’m currently taking are 2 grams of glycine before bed, 1 gram middle of the night, one 500 mg. capsule choline/inositol before bed, and one in the middle of the night, and 2 grams of l-glutamine in divided doses on an empty stomach with BCAAs (which are helping lessen the duration and severity of PEM).