Right, you have to do both - avoid the toxin and do methylation supps, as they both affect methylation. This is the thing that a lot of people don't seem to get - you will likely have to do a total program addressing all aspects that affect methylation, not just taking methylation supps and thinking it will fix everything. You might get lucky and one aspect will be extremely helpful, but that doesn't occur for most people. So you have to do an overall assessment and treat all aspects: 1. any toxins still going in - get rid of the source of those 2. any ongoing infections - get rid of those 3. gut problems - address those 4. poorly operating methylation cycle - address that 5. still have metals despite killing gut bugs and addressing methylation (both of which will detox metals) - do further metal detox 6. you have a great deal of ongoing stress or past trauma still causing issues - address that 7. nutritional deficiencies - test for and supplement for those I'm probably missing something, but you get the idea. All of these things affect methylation, therefore you have to do all of them to completely address methylation and get back in balance.