The last couple of weeks i have been waking up exhausted for the first few hours as well as feeling very achey and noticed it was getting harder and harder to get to sleep and or my sleep quality was crap. I didnt really feel like i was crashing or viral reactivation etc just feeling out of sorts. Then hit hit me yesterday that its my sleep rhthyms that are out of whack which i not only class as melatonin but also cortisol cycle. I really think my cortisol cycle was shifting for the worse, low in the morning, and late afternoon / early night i felt alot better. So last night i added phosphatidylserine (PS)500mg back into my sleep stack, i also took some tramadol SR as well to help with the pain, generally its not sedating at all for me. I was starting to think maybe i was getting a tolerence to my sleep meds and time to back off some, but if cortisol was high then sleep meds are going to struggle getting me to sleep. But i slept well last night and woke up refreshed, maybe getting cortisol in the morning?? plus the sheets werent rolled up in a ball like normal from the tossing and turning from back pain etc so tramadol helped there with pain which was also disturbing my sleep especially the later half. i think the lyrica helps pain in the firsy half of the night but not the second half, maybe just doesnt work long enough. I stopped the PS a while back as i think it was lowering my overall cortisol too much, so took a break for abit. Now PS is back in the sleep regime for awhile. maybe need to work in a lower dose after awhile?? I just think our dysfunctional bodies/brain are always pushing against us, we add something to it and it over adjusts etc. Always the need to reasses whats causing symptoms. Its only one night so far but i 'think' its more to do with cortisol cycle, not infection/immune issues which seem to be on track, for now?? Can this dam body stop over or under adjusting to everything we do to it and just act normal?? cheers!!!