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Altered sympathetic reactivity & norepinephrine transporter expression in POTS

Discussion in 'Problems Standing: Orthostatic Intolerance; POTS' started by Allyson, Jan 31, 2014.

  1. Allyson

    Allyson Senior Member

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    Australia, Melbourne
    medical article on POTS

    CONCLUSIONS: Patients with POTS exhibit a decrease in NET protein in their peripheral sympathetic nerves. Paradoxically, whole-body NE spillover to plasma during rest in the supine position and in response to head-up tilt is not altered despite excessive nerve firing rate in response to the head-up tilt.

    http://www.ncbi.nlm.nih.gov/pubmed/19808400

    A
    Last edited by a moderator: Jan 31, 2014
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  2. Valentijn

    Valentijn Activity Level: 3

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    I had a quick look at the gene which produces NET, SLC6A2, to see how rare the SNPs are for ME/CFS patients. Purple = 0 - 1% prevalence for that genotype, red = 1 - 2.5%, orange = 2.5 - 5%, and yellow = 5 - 10%. Items with a bolded and underlined RSID have research associated with them.

    SLC6A2.gif

    So 4 of us have some pretty rare genotypes, and a couple more have multiple less-rare genotypes, compared to just one control showing much rareness.
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  3. bel canto

    bel canto Senior Member

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    rs168924
    rs2242446
    rs3785143
    rs17247999
    rs17841329
    rs187715
    rs36023
    rs3785152
    rs40147
    rs12443955
    rs10521329
    rs880711
    rs3785157
    rs5568
    rs1566652
    rs8047672
    rs5569
    rs998424
    rs36009
    rs1800887
    rs36007
    rs15534
    rs42460
    rs7194256
    rs10521330

    The plug -n for firefox doesn't work for the snp's in the data tables, so I'm retyping them in the hope that the plug-in will work for these.
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  4. alex3619

    alex3619 Senior Member

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    Probable mechanism. However, why is this happening? Genetics may explain increased vulnerability, but I am not yet sure that is the whole thing. One thing I would really want to see is staining for enteroviruses in the same veins they are testing for norepinephrine transporters. It would also be interesting to investigate for antibody issues with this tissue.

    According to Wikipedia, one associated gene defect in NET is linked to orthostatic intolerance. http://en.wikipedia.org/wiki/Norepinephrine_transporter

    It would be interested to see if the same NET problem is also present in non-POTS ME patients with OI.

    A NET defect is also probably responsible for considerable cognitive problems. If this is found in ME with or without POTS, it may directly explain many of our symptoms. It still leaves why this is happening unexplained.
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  5. Valentijn

    Valentijn Activity Level: 3

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    It won't let me upload excel sheets, so these are screenshots.
  6. Valentijn

    Valentijn Activity Level: 3

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    That SNP isn't tested by 23andMe.

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