I recently learned about Freddd's Protocol and thought I should try it. I havr had the best success in the past with diet and supplements/detox. I also recently learned I have a MTHR mutation (can't remember which one). But I was looking at one of the supplements I take which I knew had some B-vitamins (among other things). It is called "Vessel Care" by Metagenics. It contains both the active b12 and the L-5 methylfolate...in high doses. I never noticed any benefit from it. Is it possible that it is because I did not start at the beginning of the protocol?