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Alpha Lipoic Acid side effects

Discussion in 'General Treatment' started by cman89, May 25, 2015.

  1. cman89

    cman89 Senior Member

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    What are possible negative effects of taking ALA (slightly) higher than the recommended dosage?
     
  2. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    You may find the answer here.
     
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  3. Gondwanaland

    Gondwanaland Senior Member

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  4. mgk

    mgk Senior Member

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    @Gondwanaland: To be fair, they were referring to very high doses in that sentence.
     
  5. Gondwanaland

    Gondwanaland Senior Member

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    If one has an already borderline low level of some mineral, it won't take much ALA to push into harmful deficiency, IMHO.
     
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  6. mgk

    mgk Senior Member

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    I don't disagree, but it's important to make a distinction between opinion/theory and scientific evidence.
     
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  7. Gondwanaland

    Gondwanaland Senior Member

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    I think it is a valid possibility that should be considered.

    One can't expect that every possible variable will be considered in a research just because it has been published.

    Additionally, the ends of a bell curve are not usually contemplated by scientific conclusions and how do you know where you fit in the bell curve?

    But I will gladly add a disclaimer to my signature.
     
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  8. mgk

    mgk Senior Member

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    I wasn't trying to make a value judgement about ALA or say that your concerns are invalid. All I was trying to say is that the sentence you quoted out of context is misleading. I mean it even begins with "In these toxic doses."
     
  9. Gondwanaland

    Gondwanaland Senior Member

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    OK my bad, but I disregarded the phrase beginning because there is no need for toxic doses to get a mineral deficiency. A modest dose can cause that when one is already borderline deficient in something, as is probably the case for most PR members. So I think this answers the original question of the thread: a mineral deficiency is possible from taking high or low dose ALA, depending on the health of who is taking it. Others will have other answers, mine is this one.

    I am finding strange that an answer of mine is getting such a reaction, because usually my answers are just ignored/dismissed as BS :confused::rolleyes:
     
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  10. mgk

    mgk Senior Member

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    It has nothing to do with you, and I'm sorry if I came across as harsh. This thread just happened to pop up while I was researching ALA. I was looking into it as a way of raising glutathione after coming across this study.
     
  11. Gondwanaland

    Gondwanaland Senior Member

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    No worries, I don't take it personally :cool:
     
  12. picante

    picante Senior Member

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    I've tried taking ALA on two or three occasions, but had the same reaction each time: Sudden Onset Intolerable Mood (that term is my own invention: it means I felt like tearing my hair out). I have a list of 7 supplements/drugs that caused that particular reaction.

    Has anyone else had any neurotransmitter-type problems with ALA?
     
  13. ahmo

    ahmo Senior Member

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    ALA has given me the same feeling as taurine, some other sulfur-containing things: excitotoxic. Sounds pretty much like you, @picante: jumping out of skin, tearing out hair. Probably some squinty eyes, can't recall the specifics now, as I just avoid them. I tried taurine again a few months ago, felt like I poisoned myself.
     
  14. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    They were also studies on RATS. Such studies are not good predictors of human effects.
     
  15. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    I don't suppose d-ribose was one of the offending supplements, was it? That made me feel as though there was a war going on inside me, and another ME sufferer said it made him want to disembowel himself!

    I'm fine with ALA though. My supplement for that also contains acetyl-l-carnitine: 200 mg alpha-lipoic acid and 250 mg acetyl-l-carnitine per day. I have occasionally accidentally taken 2 tablets and have still been fine.
     
  16. picante

    picante Senior Member

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    :jaw-drop:Holy crappola. Nope, I've never tried D-ribose, and you've just saved me a lot of :moneybag:, because it's expensive.

    My list of supplements that triggered SOIM (Sudden Onset Intolerable Mood):
    DMSA (1st or 2nd day)
    Enzyme formulas w protease (2nd dose): mood reaction or sharp abdominal pain.
    Nystatin (sporadically)
    Betaine hydrochloride (1 dose)
    Lifelink brand DHEA (1 dose)
    Zymex (kills candida)
    Alpha Lipoic Acid (3rd day)​
     
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  17. cman89

    cman89 Senior Member

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    That site was a treasure trove of awesome info. thanks .
     
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  18. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    Some people say that they find d-ribose helpful, but Dr Cheney found that about a third of his patients cannot tolerate it. There are several threads on d-ribose.
     
  19. ebethc

    ebethc Senior Member

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    I am working my way out of a crash which - I believe - was induced by ALA... I've been wondering if it "chelated" some GOOD minerals... afterall, can ALA really distinguish between what's good for your body and what's not? I don't have a mercury problem (haven't had mercury fillings in years, and I hardly ever eat tuna)
     
  20. cman89

    cman89 Senior Member

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    It can also drop blood sugar, so if you are not diabetic , that could actually be a problem.
     
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