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alpha-ketoglutarate levels?

Discussion in 'General ME/CFS Discussion' started by Kimsie, Nov 22, 2014.

  1. Kimsie

    Kimsie Senior Member

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    Mary shared her labs with me and it turns out that her alpha-ketoglutarate levels were high. I have been researching and it turns out that high alpha-ketoglutarate levels can inhibit ATP synthase (which makes ATP) at least in non-human studies, so this may or may not be true in humans.

    I was wondering if any others here have had high alpha-ketoglutarate levels?

    Thanks,
    Kim
     
  2. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Processing of alpha ketoglutarate requires NAD. There are whole threads devoted to the NAD problem.

    See the Krebs cycle here: http://en.wikipedia.org/wiki/File:Citric_acid_cycle_with_aconitate_2.svg

    aKG is on the lower right of the cycle.

    I suspect the coenzyme A is critically dependent on the methylation cycle working, expecially the path leading to glutathione.

    I have not had this tested in a decade and a half. I will have to see if I can find my old testing.
     
  3. Kimsie

    Kimsie Senior Member

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    That would be great if you still have it.

    I have been having a long conversation with Mary about NAD and how to increase it. Maybe I should share my ideas now, or maybe I should wait until Mary has a chance to test them. I believe that in CFS alpha-ketoglutarate is inhibited by high NADH levels due to inhibition of the electron transport chain. This would be true whether the AKG is high or low, but it might be that the people with higher AKG have worse symptoms.
     
  4. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    If people with higher aKG have worse symptoms we might be able to find an indicator of that with a poll.
     

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