A New Decade of ME Research: The 11th Invest in ME International ME Conference 2016
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Allopregnenelone the missing ingredient?

Discussion in 'Adrenal Dysfunction' started by drob31, Mar 12, 2016.

  1. drob31

    drob31 Senior Member

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    It's kind of a tricky thing to raise because when you take it's precursors, such as progesterone or cortisol, you end up raising and potentially unbalancing many other hormones.

    It seems progesterone is the closest you can get...

    https://en.wikipedia.org/wiki/Allopregnanolone



    https://en.wikipedia.org/wiki/Ganaxolone



    So what's the point drob31?

    I think cortisol and DHEA aren't the only two culprits when pregnenelone is low.

    Furthermore, pregnenelone steal may be occuring because of low cortisol, but cortisol itself may be diverting down a specific pathway, and also starves the body of allopregnenolone, since progesterone reserves are used up.

    Perhaps the pregnenelone is stolen to begin with for production of cortisol and non-allopregnenelone metabolites because inflammation in the body.
     
  2. WoolPippi

    WoolPippi Senior Member

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    I supplement both Progesteron and Hydrocortison, hopefully preventing Pregnenolone steal.

    If I take too much Prog. it's converted (back) into Pregnenolone and it's the most wonderful feeling! I get so sleepy and I sleep so soundly and restoring. I'd love to take Pregnenolone on its own. If I'd only dare...

    (Too much cortisol never ends up in Pregnenolone (in me anyway). I just get extremely hungry and active.)

    I don't know my levels of Pregnenolone.
    I do know DHEAs is low but that's of little clinical significance my dr. tells me. I once supplemented DHEA and I felt great, probably because it was used to make Testosterone.

    Something else to consider: my CYP2C19*17 is faulty. This liver enzym syphons away any Progesteron it finds in the blood. Causing Prog. deficiency in both male and female alike. No matter what adrenal state or Pregnenolone levels they have.
    Oral supplementation poses a problem in people who are homozygous for this gene. It breaks down substrates (like Prog. and Test.) way too fast, we need much higher doses.
    But for drugs that need this enzym to convert them into active ingredients we need much lower doses because it will flood the blood with it (for example blood thinners).

    Here's an interesting site telling you which enzymes are needed to handle which drugs: http://www.drugbank.ca/
     

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